5UE9
WT DHODB with orotate bound
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0004589 | molecular_function | dihydroorotate dehydrogenase (NAD+) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006222 | biological_process | UMP biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0009055 | molecular_function | electron transfer activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
C | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
C | 0004589 | molecular_function | dihydroorotate dehydrogenase (NAD+) activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0006222 | biological_process | UMP biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0009055 | molecular_function | electron transfer activity |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0046872 | molecular_function | metal ion binding |
D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
D | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | binding site for residue FMN A 401 |
Chain | Residue |
A | SER24 |
A | ASN197 |
A | THR198 |
A | SER221 |
A | GLY222 |
A | MET247 |
A | GLY248 |
A | GLY249 |
A | GLY270 |
A | THR271 |
A | ORO402 |
A | GLY25 |
A | HOH507 |
A | LYS48 |
A | ALA49 |
A | ASN72 |
A | ASN104 |
A | ASN132 |
A | LYS170 |
A | ILE196 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue ORO A 402 |
Chain | Residue |
A | LYS48 |
A | ASN72 |
A | ALA73 |
A | ILE74 |
A | GLY75 |
A | LEU76 |
A | ASN132 |
A | ASN197 |
A | THR198 |
A | FMN401 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CL A 403 |
Chain | Residue |
A | THR51 |
A | HIS53 |
A | ARG55 |
site_id | AC4 |
Number of Residues | 16 |
Details | binding site for residue FAD B 301 |
Chain | Residue |
B | ARG53 |
B | PRO54 |
B | ILE55 |
B | SER56 |
B | LEU70 |
B | TYR71 |
B | ARG72 |
B | SER78 |
B | GLY79 |
B | THR80 |
B | ILE120 |
B | GLU221 |
B | SER222 |
B | ARG223 |
B | MET224 |
B | HOH407 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue FES B 302 |
Chain | Residue |
B | ALA225 |
B | CYS226 |
B | GLY227 |
B | GLY229 |
B | CYS231 |
B | TYR232 |
B | ALA233 |
B | CYS234 |
B | CYS249 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue GOL B 303 |
Chain | Residue |
B | GLY144 |
B | PHE145 |
B | ASP170 |
B | GLY178 |
B | HIS179 |
B | VAL180 |
site_id | AC7 |
Number of Residues | 15 |
Details | binding site for residue FAD D 301 |
Chain | Residue |
D | ARG53 |
D | PRO54 |
D | ILE55 |
D | SER56 |
D | LEU70 |
D | TYR71 |
D | ARG72 |
D | SER78 |
D | GLY79 |
D | THR80 |
D | ILE120 |
D | GLU221 |
D | SER222 |
D | ARG223 |
D | MET224 |
site_id | AC8 |
Number of Residues | 9 |
Details | binding site for residue FES D 302 |
Chain | Residue |
D | ALA225 |
D | CYS226 |
D | GLY227 |
D | GLY229 |
D | ALA230 |
D | CYS231 |
D | TYR232 |
D | CYS234 |
D | CYS249 |
site_id | AC9 |
Number of Residues | 21 |
Details | binding site for residue FMN C 401 |
Chain | Residue |
C | THR198 |
C | SER221 |
C | GLY222 |
C | MET247 |
C | GLY248 |
C | GLY249 |
C | GLY270 |
C | THR271 |
C | ORO402 |
C | HOH505 |
C | ALA23 |
C | SER24 |
C | GLY25 |
C | LYS48 |
C | ALA49 |
C | ASN72 |
C | ASN104 |
C | ASN132 |
C | LYS170 |
C | ILE196 |
C | ASN197 |
site_id | AD1 |
Number of Residues | 8 |
Details | binding site for residue ORO C 402 |
Chain | Residue |
C | ASN72 |
C | ILE74 |
C | GLY75 |
C | LEU76 |
C | ASN132 |
C | ASN197 |
C | THR198 |
C | FMN401 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue GOL C 403 |
Chain | Residue |
C | ARG55 |
C | ASN78 |
C | PRO79 |
C | HOH515 |
D | ASN243 |
D | HIS244 |
D | ALA245 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01211 |
Chain | Residue | Details |
B | ARG53 | |
D | GLY79 | |
D | CYS226 | |
D | CYS231 | |
D | CYS234 | |
D | CYS249 | |
B | LEU70 | |
B | GLY79 | |
B | CYS226 | |
B | CYS231 | |
B | CYS234 | |
B | CYS249 | |
D | ARG53 | |
D | LEU70 |
site_id | SWS_FT_FI2 |
Number of Residues | 22 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | SER24 | |
A | GLY248 | |
A | GLY270 | |
C | SER24 | |
C | LYS48 | |
C | ASN72 | |
C | ASN104 | |
C | ASN132 | |
C | LYS170 | |
C | ILE196 | |
C | ASN197 | |
A | LYS48 | |
C | GLY222 | |
C | GLY248 | |
C | GLY270 | |
A | ASN72 | |
A | ASN104 | |
A | ASN132 | |
A | LYS170 | |
A | ILE196 | |
A | ASN197 | |
A | GLY222 |