5UDY

Human alkaline sphingomyelinase (alk-SMase, ENPP7, NPP7)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004767	molecular_function	sphingomyelin phosphodiesterase activity
A	0006685	biological_process	sphingomyelin catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	411
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ALA22-SER433

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:28292932

Chain	Residue	Details
A	THR75

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site_id	SWS_FT_FI3
Number of Residues	7
Details	BINDING: BINDING => ECO:0000305|PubMed:28292932, ECO:0007744|PDB:5TCD, ECO:0007744|PDB:5UDY

Chain	Residue	Details
A	ASP39
A	THR75
A	ASP199
A	HIS203
A	ASP246
A	HIS247
A	HIS353

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:28292932, ECO:0007744|PDB:5TCD

Chain	Residue	Details
A	ASN96

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site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15458386, ECO:0000269|PubMed:28292932, ECO:0007744|PDB:5TCD, ECO:0007744|PDB:5UDY

Chain	Residue	Details
A	ASN100
A	ASN121
A	ASN168

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15458386, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:28292932, ECO:0007744|PDB:5TCD, ECO:0007744|PDB:5UDY

Chain	Residue	Details
A	ASN146

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15458386, ECO:0000269|PubMed:28292932, ECO:0007744|PDB:5TCD

Chain	Residue	Details
A	ASN267

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