5UDY

Human alkaline sphingomyelinase (alk-SMase, ENPP7, NPP7)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004767	molecular_function	sphingomyelin phosphodiesterase activity
A	0006685	biological_process	sphingomyelin catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Region: {"description":"Required for enzyme activity","evidences":[{"source":"PubMed","id":"15458386","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"28292932","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28292932","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UDY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28292932","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TCD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15458386","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28292932","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UDY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15458386","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28292932","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UDY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15458386","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28292932","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TCD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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