5UAV
Structure of human PYCR-1 complexed with NADPH and L-tetrahydrofuroic acid
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006561 | biological_process | proline biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0034599 | biological_process | cellular response to oxidative stress |
A | 0042802 | molecular_function | identical protein binding |
A | 0051881 | biological_process | regulation of mitochondrial membrane potential |
A | 0055129 | biological_process | L-proline biosynthetic process |
A | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
B | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006561 | biological_process | proline biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0034599 | biological_process | cellular response to oxidative stress |
B | 0042802 | molecular_function | identical protein binding |
B | 0051881 | biological_process | regulation of mitochondrial membrane potential |
B | 0055129 | biological_process | L-proline biosynthetic process |
B | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
C | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005739 | cellular_component | mitochondrion |
C | 0005759 | cellular_component | mitochondrial matrix |
C | 0006561 | biological_process | proline biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0034599 | biological_process | cellular response to oxidative stress |
C | 0042802 | molecular_function | identical protein binding |
C | 0051881 | biological_process | regulation of mitochondrial membrane potential |
C | 0055129 | biological_process | L-proline biosynthetic process |
C | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
D | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005739 | cellular_component | mitochondrion |
D | 0005759 | cellular_component | mitochondrial matrix |
D | 0006561 | biological_process | proline biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0034599 | biological_process | cellular response to oxidative stress |
D | 0042802 | molecular_function | identical protein binding |
D | 0051881 | biological_process | regulation of mitochondrial membrane potential |
D | 0055129 | biological_process | L-proline biosynthetic process |
D | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
E | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005739 | cellular_component | mitochondrion |
E | 0005759 | cellular_component | mitochondrial matrix |
E | 0006561 | biological_process | proline biosynthetic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0034599 | biological_process | cellular response to oxidative stress |
E | 0042802 | molecular_function | identical protein binding |
E | 0051881 | biological_process | regulation of mitochondrial membrane potential |
E | 0055129 | biological_process | L-proline biosynthetic process |
E | 1903377 | biological_process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 30 |
Details | binding site for residue NDP A 401 |
Chain | Residue |
A | GLY7 |
A | ASN56 |
A | ALA69 |
A | VAL70 |
A | LYS71 |
A | PRO72 |
A | ILE78 |
A | CYS95 |
A | ALA96 |
A | ALA97 |
A | MET121 |
A | ALA8 |
A | THR122 |
A | THR124 |
A | HOH518 |
A | HOH534 |
A | HOH538 |
A | HOH556 |
A | HOH562 |
B | ASN230 |
B | VAL231 |
B | TFB402 |
A | GLY9 |
B | HOH581 |
A | GLN10 |
A | LEU11 |
A | SER33 |
A | SER34 |
A | PRO35 |
A | ASP36 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue TFB A 402 |
Chain | Residue |
A | GLY236 |
A | ALA237 |
A | THR238 |
A | HOH501 |
A | HOH508 |
A | HOH539 |
B | GLY175 |
B | NDP401 |
site_id | AC3 |
Number of Residues | 31 |
Details | binding site for residue NDP B 401 |
Chain | Residue |
A | TFB402 |
A | HOH508 |
A | HOH571 |
B | GLY7 |
B | ALA8 |
B | GLY9 |
B | GLN10 |
B | LEU11 |
B | SER33 |
B | SER34 |
B | PRO35 |
B | ASP36 |
B | ASN56 |
B | ALA69 |
B | VAL70 |
B | LYS71 |
B | PRO72 |
B | ILE78 |
B | CYS95 |
B | ALA96 |
B | ALA97 |
B | MET121 |
B | THR122 |
B | THR124 |
B | HOH512 |
B | HOH513 |
B | HOH514 |
B | HOH554 |
B | HOH557 |
B | HOH564 |
B | HOH575 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue TFB B 402 |
Chain | Residue |
A | GLY175 |
A | NDP401 |
B | VAL231 |
B | SER233 |
B | ALA237 |
B | THR238 |
B | HOH503 |
B | HOH533 |
site_id | AC5 |
Number of Residues | 36 |
Details | binding site for residue NDP C 401 |
Chain | Residue |
C | HOH508 |
C | HOH531 |
C | HOH532 |
C | HOH535 |
C | HOH540 |
C | HOH553 |
C | HOH564 |
C | HOH566 |
C | HOH572 |
C | HOH573 |
C | HOH592 |
C | HOH618 |
D | VAL231 |
D | TFB402 |
C | GLY7 |
C | ALA8 |
C | GLY9 |
C | GLN10 |
C | LEU11 |
C | SER34 |
C | PRO35 |
C | ASP36 |
C | MET37 |
C | ASN56 |
C | ALA69 |
C | VAL70 |
C | LYS71 |
C | PRO72 |
C | ILE78 |
C | CYS95 |
C | ALA96 |
C | ALA97 |
C | MET121 |
C | THR122 |
C | THR124 |
C | HOH503 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue TFB C 402 |
Chain | Residue |
C | SER233 |
C | ALA237 |
C | THR238 |
C | HOH515 |
D | THR171 |
D | GLY175 |
D | NDP401 |
D | HOH541 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue PEG C 403 |
Chain | Residue |
B | ASP64 |
B | ARG89 |
C | LEU39 |
C | HOH600 |
site_id | AC8 |
Number of Residues | 31 |
Details | binding site for residue NDP D 401 |
Chain | Residue |
C | VAL231 |
C | TFB402 |
C | HOH565 |
D | GLY7 |
D | ALA8 |
D | GLY9 |
D | GLN10 |
D | LEU11 |
D | SER33 |
D | SER34 |
D | PRO35 |
D | ASP36 |
D | ASN56 |
D | ALA69 |
D | VAL70 |
D | LYS71 |
D | PRO72 |
D | ILE78 |
D | CYS95 |
D | ALA96 |
D | ALA97 |
D | MET121 |
D | THR122 |
D | THR124 |
D | HOH515 |
D | HOH520 |
D | HOH541 |
D | HOH550 |
D | HOH566 |
D | HOH572 |
D | HOH600 |
site_id | AC9 |
Number of Residues | 10 |
Details | binding site for residue TFB D 402 |
Chain | Residue |
C | THR171 |
C | GLY175 |
C | NDP401 |
C | HOH508 |
D | SER233 |
D | GLY236 |
D | ALA237 |
D | THR238 |
D | HOH502 |
D | HOH526 |
site_id | AD1 |
Number of Residues | 33 |
Details | binding site for residue NDP E 401 |
Chain | Residue |
E | GLY7 |
E | ALA8 |
E | GLY9 |
E | GLN10 |
E | LEU11 |
E | SER34 |
E | PRO35 |
E | ASP36 |
E | MET37 |
E | ASN56 |
E | ALA69 |
E | VAL70 |
E | LYS71 |
E | PRO72 |
E | ILE78 |
E | CYS95 |
E | ALA96 |
E | ALA97 |
E | MET121 |
E | THR122 |
E | THR124 |
E | ASN230 |
E | VAL231 |
E | TFB402 |
E | HOH515 |
E | HOH522 |
E | HOH530 |
E | HOH538 |
E | HOH553 |
E | HOH555 |
E | HOH558 |
E | HOH579 |
E | HOH588 |
site_id | AD2 |
Number of Residues | 9 |
Details | binding site for residue TFB E 402 |
Chain | Residue |
E | THR171 |
E | GLY175 |
E | VAL231 |
E | SER233 |
E | ALA237 |
E | THR238 |
E | NDP401 |
E | HOH515 |
E | HOH550 |
Functional Information from PROSITE/UniProt
site_id | PS00521 |
Number of Residues | 23 |
Details | P5CR Delta 1-pyrroline-5-carboxylate reductase signature. Pgq.LkdnVSSpGGaTihALhvLE |
Chain | Residue | Details |
A | PRO224-GLU246 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 25 |
Details | BINDING: BINDING => ECO:0000269|Ref.18 |
Chain | Residue | Details |
A | ILE6 | |
B | CYS95 | |
C | ILE6 | |
C | SER34 | |
C | ASN56 | |
C | ALA69 | |
C | CYS95 | |
D | ILE6 | |
D | SER34 | |
D | ASN56 | |
D | ALA69 | |
A | SER34 | |
D | CYS95 | |
E | ILE6 | |
E | SER34 | |
E | ASN56 | |
E | ALA69 | |
E | CYS95 | |
A | ASN56 | |
A | ALA69 | |
A | CYS95 | |
B | ILE6 | |
B | SER34 | |
B | ASN56 | |
B | ALA69 |
site_id | SWS_FT_FI2 |
Number of Residues | 5 |
Details | MOD_RES: N-acetylserine => ECO:0000269|Ref.8, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330 |
Chain | Residue | Details |
A | SER2 | |
B | SER2 | |
C | SER2 | |
D | SER2 | |
E | SER2 |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER278 | |
B | SER278 | |
C | SER278 | |
D | SER278 | |
E | SER278 |