Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0045454 | biological_process | cell redox homeostasis |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 39 |
| Details | binding site for residue FAD A 401 |
| Chain | Residue |
| A | GLY13 |
| A | GLY42 |
| A | GLN43 |
| A | LEU44 |
| A | THR47 |
| A | ILE50 |
| A | ASN52 |
| A | HIS84 |
| A | ILE85 |
| A | ALA112 |
| A | THR113 |
| A | SER14 |
| A | GLY114 |
| A | ALA115 |
| A | GLU160 |
| A | HIS245 |
| A | GLY285 |
| A | ASP286 |
| A | ARG293 |
| A | GLN294 |
| A | ALA295 |
| A | SER298 |
| A | GLY15 |
| A | ACT405 |
| A | HOH512 |
| A | HOH515 |
| A | HOH532 |
| A | HOH539 |
| A | HOH543 |
| A | HOH561 |
| A | HOH620 |
| A | HOH626 |
| B | TYR24 |
| A | PRO16 |
| A | ALA17 |
| A | THR36 |
| A | GLY37 |
| A | LEU38 |
| A | GLN39 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | ALA26 |
| A | ASN29 |
| A | PHE76 |
| A | GLU77 |
| B | HOH546 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | GLY268 |
| A | HOH503 |
| B | SER267 |
| B | GOL404 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | ARG177 |
| A | GLY254 |
| A | LEU256 |
| A | GLU257 |
| A | HOH623 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 405 |
| Chain | Residue |
| A | GLY37 |
| A | LEU38 |
| A | HIS84 |
| A | FAD401 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 406 |
| Chain | Residue |
| A | HIS176 |
| A | SER180 |
| A | ARG182 |
| A | NAP407 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue NAP A 407 |
| Chain | Residue |
| A | ARG118 |
| A | GLY154 |
| A | GLY155 |
| A | HIS176 |
| A | ARG177 |
| A | ARG178 |
| A | ARG182 |
| A | ILE243 |
| A | GLY244 |
| A | HIS245 |
| A | GLY254 |
| A | ACT406 |
| A | HOH555 |
| A | HOH582 |
| A | HOH593 |
| A | HOH594 |
| A | HOH652 |
| site_id | AC8 |
| Number of Residues | 38 |
| Details | binding site for residue FAD B 401 |
| Chain | Residue |
| B | ALA115 |
| B | HIS245 |
| B | GLY285 |
| B | ASP286 |
| B | ARG293 |
| B | GLN294 |
| B | ALA295 |
| B | SER298 |
| B | ACT405 |
| B | HOH511 |
| B | HOH522 |
| B | HOH529 |
| B | HOH532 |
| B | HOH542 |
| B | HOH543 |
| B | HOH551 |
| B | HOH620 |
| A | TYR24 |
| B | GLY13 |
| B | SER14 |
| B | GLY15 |
| B | PRO16 |
| B | ALA17 |
| B | THR36 |
| B | GLY37 |
| B | LEU38 |
| B | GLN39 |
| B | GLY42 |
| B | GLN43 |
| B | LEU44 |
| B | THR47 |
| B | ILE50 |
| B | ASN52 |
| B | HIS84 |
| B | ILE85 |
| B | ALA112 |
| B | THR113 |
| B | GLY114 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| A | LYS193 |
| A | GLU196 |
| B | MET59 |
| B | THR60 |
| B | THR61 |
| B | GLY64 |
| B | NA407 |
| B | HOH549 |
| B | HOH592 |
| B | HOH600 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| A | ILE186 |
| A | HOH571 |
| B | ALA26 |
| B | ASN29 |
| B | PHE76 |
| B | GLU77 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| A | SER267 |
| A | MET288 |
| A | GOL403 |
| B | GLY268 |
| B | HOH531 |
| B | HOH573 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 405 |
| Chain | Residue |
| B | GLY37 |
| B | LEU38 |
| B | HIS84 |
| B | FAD401 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for residue NAP B 406 |
| Chain | Residue |
| B | ARG118 |
| B | GLY154 |
| B | GLY155 |
| B | HIS176 |
| B | ARG177 |
| B | ARG178 |
| B | ILE243 |
| B | GLY244 |
| B | HIS245 |
| B | ARG293 |
| B | HOH580 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 407 |
| Chain | Residue |
| B | MET59 |
| B | GOL402 |
| B | HOH549 |
| B | HOH600 |
| B | HOH601 |
| B | HOH624 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CatCDGff..YrnkpVgVIGGGN |
| Chain | Residue | Details |
| A | CYS136-ASN156 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | THR36 | |
| A | ASP286 | |
| B | THR36 | |
| B | ASP286 | |
