5U5H
Crystal structure of EED in complex with 6-(2-fluoro-5-methoxybenzyl)-1-isopropyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine 6-(2-fluoro-5-methoxybenzyl)-1-isopropyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016571 | biological_process | histone methylation |
| A | 0035098 | cellular_component | ESC/E(Z) complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 7VV A 501 |
| Chain | Residue |
| A | PHE97 |
| A | ARG414 |
| A | ASN194 |
| A | GLU238 |
| A | LEU240 |
| A | MET256 |
| A | ASP310 |
| A | TYR365 |
| A | MET366 |
| A | ARG367 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ASP155 |
| A | SER156 |
| A | ASN157 |
| A | ASN204 |
| A | GLN221 |
| A | HOH698 |
| A | HOH771 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI |
| Chain | Residue | Details |
| A | LEU206-ILE220 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 1"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 2"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 3"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 4"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 5"} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 154 |
| Details | Region: {"description":"Required for interaction with the matrix protein MA of HIV-1"} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]} |
