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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5U3C

CryoEM structure of the CTP synthase filament at 4.6 Angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0003883molecular_functionCTP synthase activity
A0004359molecular_functionglutaminase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0006241biological_processCTP biosynthetic process
A0016874molecular_functionligase activity
A0019856biological_processpyrimidine nucleobase biosynthetic process
A0032991cellular_componentprotein-containing complex
A0042802molecular_functionidentical protein binding
A0044210biological_process'de novo' CTP biosynthetic process
A0046872molecular_functionmetal ion binding
A0051289biological_processprotein homotetramerization
A0097268cellular_componentcytoophidium
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0003883molecular_functionCTP synthase activity
B0004359molecular_functionglutaminase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0006241biological_processCTP biosynthetic process
B0016874molecular_functionligase activity
B0019856biological_processpyrimidine nucleobase biosynthetic process
B0032991cellular_componentprotein-containing complex
B0042802molecular_functionidentical protein binding
B0044210biological_process'de novo' CTP biosynthetic process
B0046872molecular_functionmetal ion binding
B0051289biological_processprotein homotetramerization
B0097268cellular_componentcytoophidium
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0003883molecular_functionCTP synthase activity
C0004359molecular_functionglutaminase activity
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006221biological_processpyrimidine nucleotide biosynthetic process
C0006241biological_processCTP biosynthetic process
C0016874molecular_functionligase activity
C0019856biological_processpyrimidine nucleobase biosynthetic process
C0032991cellular_componentprotein-containing complex
C0042802molecular_functionidentical protein binding
C0044210biological_process'de novo' CTP biosynthetic process
C0046872molecular_functionmetal ion binding
C0051289biological_processprotein homotetramerization
C0097268cellular_componentcytoophidium
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0003883molecular_functionCTP synthase activity
D0004359molecular_functionglutaminase activity
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006221biological_processpyrimidine nucleotide biosynthetic process
D0006241biological_processCTP biosynthetic process
D0016874molecular_functionligase activity
D0019856biological_processpyrimidine nucleobase biosynthetic process
D0032991cellular_componentprotein-containing complex
D0042802molecular_functionidentical protein binding
D0044210biological_process'de novo' CTP biosynthetic process
D0046872molecular_functionmetal ion binding
D0051289biological_processprotein homotetramerization
D0097268cellular_componentcytoophidium
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue CTP A 601
ChainResidue
AASP147
AILE148
AGLU149
BGLN114
BVAL115
BILE116
CTHR188
CLYS189
CLYS196
site_idAC2
Number of Residues9
Detailsbinding site for residue ADP A 602
ChainResidue
ALEU16
AGLY17
ALYS18
AILE20
AASP72
AARG211
ALYS239
AASP240
AVAL241
site_idAC3
Number of Residues8
Detailsbinding site for residue CTP B 601
ChainResidue
AGLN114
BSER14
BASP147
BILE148
BGLU149
DTHR188
DLYS189
DLYS196
site_idAC4
Number of Residues9
Detailsbinding site for residue ADP B 602
ChainResidue
BLEU16
BGLY17
BLYS18
BGLY19
BILE20
BARG211
BLYS239
BASP240
BVAL241
site_idAC5
Number of Residues8
Detailsbinding site for residue CTP C 601
ChainResidue
ATHR188
ALYS189
ALYS196
CSER14
CASP147
CILE148
CGLU149
DGLN114
site_idAC6
Number of Residues10
Detailsbinding site for residue ADP C 602
ChainResidue
CLEU16
CGLY17
CLYS18
CGLY19
CILE20
CASP72
CARG211
CLYS239
CASP240
CVAL241
site_idAC7
Number of Residues8
Detailsbinding site for residue CTP D 601
ChainResidue
BTHR188
BLYS189
BLYS196
CILE116
DSER14
DASP147
DILE148
DGLU149
site_idAC8
Number of Residues9
Detailsbinding site for residue ADP D 602
ChainResidue
DLEU16
DGLY17
DLYS18
DGLY19
DILE20
DARG211
DLYS239
DASP240
DVAL241
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1060
DetailsRegion: {"description":"Amidoligase domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01227","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Nucleophile; for glutamine hydrolysis","evidences":[{"source":"PubMed","id":"11336655","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15157079","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsActive site: {"evidences":[{"source":"PubMed","id":"15157079","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16216072","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16216072","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2AD5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16216072","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AD5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01227","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1056
DetailsRegion: {"description":"Amidoligase domain","evidences":[{"source":"PubMed","id":"15157079","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2025-10-22

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