5U1O
2.3 Angstrom Resolution Crystal Structure of Glutathione Reductase from Vibrio parahaemolyticus in Complex with FAD.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006749 | biological_process | glutathione metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0045454 | biological_process | cell redox homeostasis |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0050661 | molecular_function | NADP binding |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006749 | biological_process | glutathione metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| D | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0045454 | biological_process | cell redox homeostasis |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0050661 | molecular_function | NADP binding |
| D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | binding site for residue FAD A 501 |
| Chain | Residue |
| A | GLY15 |
| A | CYS46 |
| A | VAL49 |
| A | GLY50 |
| A | CYS51 |
| A | LYS54 |
| A | GLY117 |
| A | PHE118 |
| A | ALA119 |
| A | ALA142 |
| A | VAL143 |
| A | GLY17 |
| A | GLY144 |
| A | TYR181 |
| A | ILE182 |
| A | ARG267 |
| A | ILE274 |
| A | GLY306 |
| A | ASP307 |
| A | GLU314 |
| A | LEU315 |
| A | THR316 |
| A | SER18 |
| A | PRO317 |
| A | HOH651 |
| A | HOH655 |
| A | HOH656 |
| A | HOH693 |
| A | HOH735 |
| B | HIS444 |
| B | PRO445 |
| A | GLY19 |
| A | ILE37 |
| A | GLU38 |
| A | ALA39 |
| A | GLY44 |
| A | THR45 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | SER378 |
| A | GLY379 |
| A | GLU450 |
| site_id | AC3 |
| Number of Residues | 36 |
| Details | binding site for residue FAD B 501 |
| Chain | Residue |
| A | HIS444 |
| A | PRO445 |
| B | GLY15 |
| B | GLY17 |
| B | SER18 |
| B | GLY19 |
| B | GLU38 |
| B | ALA39 |
| B | GLY44 |
| B | THR45 |
| B | CYS46 |
| B | GLY50 |
| B | CYS51 |
| B | LYS54 |
| B | GLY117 |
| B | PHE118 |
| B | ALA119 |
| B | ALA142 |
| B | VAL143 |
| B | GLY144 |
| B | TYR181 |
| B | ILE182 |
| B | ARG267 |
| B | ILE274 |
| B | GLY306 |
| B | ASP307 |
| B | GLU314 |
| B | LEU315 |
| B | THR316 |
| B | PRO317 |
| B | HOH655 |
| B | HOH669 |
| B | HOH671 |
| B | HOH694 |
| B | HOH715 |
| B | HOH716 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | SER378 |
| B | GLY379 |
| B | GLU450 |
| B | HOH739 |
| site_id | AC5 |
| Number of Residues | 38 |
| Details | binding site for residue FAD C 501 |
| Chain | Residue |
| C | GLY144 |
| C | TYR181 |
| C | ILE182 |
| C | ARG267 |
| C | ILE274 |
| C | GLY306 |
| C | ASP307 |
| C | GLU314 |
| C | LEU315 |
| C | THR316 |
| C | PRO317 |
| C | HOH623 |
| C | HOH625 |
| C | HOH640 |
| C | HOH652 |
| C | HOH664 |
| C | HOH683 |
| D | HIS444 |
| D | PRO445 |
| C | GLY15 |
| C | GLY17 |
| C | SER18 |
| C | GLY19 |
| C | GLU38 |
| C | ALA39 |
| C | ASP41 |
| C | GLY44 |
| C | THR45 |
| C | CYS46 |
| C | VAL49 |
| C | GLY50 |
| C | CYS51 |
| C | LYS54 |
| C | GLY117 |
| C | PHE118 |
| C | ALA119 |
| C | ALA142 |
| C | VAL143 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 502 |
| Chain | Residue |
| C | SER378 |
| C | GLY379 |
| C | GLU450 |
| site_id | AC7 |
| Number of Residues | 38 |
| Details | binding site for residue FAD D 501 |
| Chain | Residue |
| C | HIS444 |
| C | PRO445 |
| D | GLY15 |
| D | GLY17 |
| D | SER18 |
| D | GLY19 |
| D | ILE37 |
| D | GLU38 |
| D | ALA39 |
| D | ASP41 |
| D | GLY44 |
| D | THR45 |
| D | CYS46 |
| D | VAL49 |
| D | GLY50 |
| D | CYS51 |
| D | LYS54 |
| D | GLY117 |
| D | PHE118 |
| D | ALA119 |
| D | ALA142 |
| D | VAL143 |
| D | GLY144 |
| D | TYR181 |
| D | ILE182 |
| D | ARG267 |
| D | ILE274 |
| D | GLY306 |
| D | ASP307 |
| D | GLU314 |
| D | LEU315 |
| D | THR316 |
| D | PRO317 |
| D | HOH614 |
| D | HOH654 |
| D | HOH660 |
| D | HOH669 |
| D | HOH705 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue CL D 502 |
| Chain | Residue |
| D | LEU343 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 503 |
| Chain | Residue |
| D | SER378 |
| D | GLY379 |
| D | GLU450 |
| D | HOH615 |
| D | HOH742 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
| Chain | Residue | Details |
| A | GLY43-PRO53 |
