Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5U17

Structure of human MR1-DA-6-FP in complex with human MAIT A-F7 TCR

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0000139	cellular_component	Golgi membrane
F	0001913	biological_process	T cell mediated cytotoxicity
F	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
F	0002237	biological_process	response to molecule of bacterial origin
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005765	cellular_component	lysosomal membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010977	biological_process	negative regulation of neuron projection development
F	0012507	cellular_component	ER to Golgi transport vesicle membrane
F	0016020	cellular_component	membrane
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
F	0023026	molecular_function	MHC class II protein complex binding
F	0030670	cellular_component	phagocytic vesicle membrane
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0031905	cellular_component	early endosome lumen
F	0032092	biological_process	positive regulation of protein binding
F	0033077	biological_process	T cell differentiation in thymus
F	0034756	biological_process	regulation of iron ion transport
F	0035580	cellular_component	specific granule lumen
F	0042026	biological_process	protein refolding
F	0042605	molecular_function	peptide antigen binding
F	0042612	cellular_component	MHC class I protein complex
F	0042613	cellular_component	MHC class II protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0045646	biological_process	regulation of erythrocyte differentiation
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0050778	biological_process	positive regulation of immune response
F	0050870	biological_process	positive regulation of T cell activation
F	0051289	biological_process	protein homotetramerization
F	0055038	cellular_component	recycling endosome membrane
F	0060586	biological_process	multicellular organismal-level iron ion homeostasis
F	0070062	cellular_component	extracellular exosome
F	0071281	biological_process	cellular response to iron ion
F	0071283	biological_process	cellular response to iron(III) ion
F	0071316	biological_process	cellular response to nicotine
F	1900121	biological_process	negative regulation of receptor binding
F	1900122	biological_process	positive regulation of receptor binding
F	1904434	biological_process	positive regulation of ferrous iron binding
F	1904437	biological_process	positive regulation of transferrin receptor binding
F	1904724	cellular_component	tertiary granule lumen
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0000139	cellular_component	Golgi membrane
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005765	cellular_component	lysosomal membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0009986	cellular_component	cell surface
H	0010977	biological_process	negative regulation of neuron projection development
H	0012507	cellular_component	ER to Golgi transport vesicle membrane
H	0016020	cellular_component	membrane
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
H	0023026	molecular_function	MHC class II protein complex binding
H	0030670	cellular_component	phagocytic vesicle membrane
H	0031901	cellular_component	early endosome membrane
H	0031902	cellular_component	late endosome membrane
H	0031905	cellular_component	early endosome lumen
H	0032092	biological_process	positive regulation of protein binding
H	0033077	biological_process	T cell differentiation in thymus
H	0034756	biological_process	regulation of iron ion transport
H	0035580	cellular_component	specific granule lumen
H	0042026	biological_process	protein refolding
H	0042605	molecular_function	peptide antigen binding
H	0042612	cellular_component	MHC class I protein complex
H	0042613	cellular_component	MHC class II protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0050778	biological_process	positive regulation of immune response
H	0050870	biological_process	positive regulation of T cell activation
H	0051289	biological_process	protein homotetramerization
H	0055038	cellular_component	recycling endosome membrane
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0070062	cellular_component	extracellular exosome
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1900121	biological_process	negative regulation of receptor binding
H	1900122	biological_process	positive regulation of receptor binding
H	1904434	biological_process	positive regulation of ferrous iron binding
H	1904437	biological_process	positive regulation of transferrin receptor binding
H	1904724	cellular_component	tertiary granule lumen
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 7WP A 301

Chain	Residue
A	TYR7
A	HOH450
A	HOH454
B	HOH411
A	ARG9
A	LYS43
A	TYR62
A	TRP69
A	ARG94
A	TRP156
A	HOH409
A	HOH442

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 302

Chain	Residue
A	GLU160
A	ALA163
A	TRP164
A	ARG167
A	HOH429
B	SER27
B	GLY28
B	SER93

site_id	AC3
Number of Residues	11
Details	binding site for residue GOL B 301

Chain	Residue
B	ASP52
B	GLY53
B	LEU54
B	GLU55
B	HOH403
E	TRP224
E	THR225
E	GLN226
E	ASP227
E	ARG228
E	ALA229

site_id	AC4
Number of Residues	12
Details	binding site for residue 7WP C 301

Chain	Residue
C	TYR7
C	ARG9
C	LYS43
C	TYR62
C	TRP69
C	ARG94
C	TRP156
C	HOH421
C	HOH423
C	HOH445
C	HOH473
D	HOH434

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL C 302

Chain	Residue
C	ALA131
C	ASP133
C	ASN134

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL C 303

Chain	Residue
C	GLU160
C	ALA163
C	TRP164
C	ARG167
C	HOH411
D	SER93

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL C 304

Chain	Residue
C	GLN42
C	GLN64
C	ARG67
E	THR54
E	THR55
E	ASP56

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL C 305

Chain	Residue
C	TYR84
C	TYR114
C	GLN117
C	ASP118
C	PHE119
C	VAL132
C	ASP133

site_id	AC9
Number of Residues	4
Details	binding site for residue ACT D 301

Chain	Residue
C	ARG167
D	SER27
D	SER93
D	HOH405

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL E 301

Chain	Residue
A	ILE210
A	MET212
A	TYR227
A	GLY228
A	TRP241
E	ASN204
E	ARG206

site_id	AD2
Number of Residues	6
Details	binding site for residue NA E 302

Chain	Residue
E	TYR47
E	PRO61
E	TYR64
E	HOH440
E	HOH466
E	HOH491

site_id	AD3
Number of Residues	6
Details	binding site for residue ACT F 101

Chain	Residue
C	ARG6
C	TYR27
C	ASP29
F	PHE56
F	LYS58
F	TYR63

site_id	AD4
Number of Residues	6
Details	binding site for residue NA G 301

Chain	Residue
G	TYR47
G	PRO61
G	TYR64
G	HOH447
G	HOH451
G	HOH491

site_id	AD5
Number of Residues	7
Details	binding site for residue GOL H 101

Chain	Residue
H	ASP96
H	HOH202
H	GLN8
H	VAL9
H	VAL93
H	LYS94
H	TRP95

site_id	AD6
Number of Residues	6
Details	binding site for residue GOL H 102

Chain	Residue
A	ARG6
A	TYR27
A	ASP29
H	PHE56
H	TYR63
H	HOH201

site_id	AD7
Number of Residues	6
Details	binding site for residue NA H 103

Chain	Residue
H	ASN83
H	HIS84
H	LEU87
H	HOH250
H	HOH259
H	HOH261

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
F	TYR78-HIS84
A	TYR254-HIS260

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269\|PubMed:7554280

Chain	Residue	Details
F	GLN2
C	GLN153
H	GLN2
A	ARG94
A	TYR152
A	GLN153
C	ARG9
C	SER24
C	ARG94
C	TYR152

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
F	ILE1
H	ILE1

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
F	LYS19
H	LYS58
H	LYS91
H	LYS94
F	LYS41
F	LYS48
F	LYS58
F	LYS91
F	LYS94
H	LYS19
H	LYS41
H	LYS48

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)