5TZY
GPR40 in complex with AgoPAM AP8 and partial agonist MK-8666
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue OLC A 2401 |
| Chain | Residue |
| A | PHE9 |
| A | GLY10 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue MK6 A 2402 |
| Chain | Residue |
| A | PHE142 |
| A | LEU171 |
| A | ARG183 |
| A | LEU186 |
| A | TYR2240 |
| A | ARG2258 |
| A | PRO80 |
| A | ALA83 |
| A | PHE87 |
| A | TYR91 |
| A | LEU135 |
| A | LEU138 |
| A | GLY139 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue 7OS A 2403 |
| Chain | Residue |
| A | TYR44 |
| A | TYR91 |
| A | GLY95 |
| A | ALA99 |
| A | TYR114 |
| A | SER123 |
| A | VAL126 |
| A | ILE130 |
| A | LEU133 |
| A | VAL134 |
| A | LEU189 |
| A | LEU190 |
| A | LEU193 |
| A | PRO194 |
| A | ILE197 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 63 |
| Details | TOPO_DOM: Extracellular => ECO:0000255, ECO:0000269|PubMed:25043059 |
| Chain | Residue | Details |
| A | MET1-SER8 | |
| A | GLU65-CYS79 | |
| A | GLY143-SER178 | |
| A | LEU2249-SER2256 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255, ECO:0000269|PubMed:25043059 |
| Chain | Residue | Details |
| A | PHE9-THR31 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255, ECO:0000269|PubMed:25043059 |
| Chain | Residue | Details |
| A | ALA32-SER41 | |
| A | ALA102-CYS121 | |
| A | GLY2280-LYS2300 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255, ECO:0000269|PubMed:25043059 |
| Chain | Residue | Details |
| A | ALA42-VAL64 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255, ECO:0000269|PubMed:25043059 |
| Chain | Residue | Details |
| A | PRO80-SER101 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255, ECO:0000269|PubMed:25043059 |
| Chain | Residue | Details |
| A | TYR122-PHE142 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255, ECO:0000269|PubMed:25043059 |
| Chain | Residue | Details |
| A | ALA179-PHE200 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255, ECO:0000269|PubMed:25043059 |
| Chain | Residue | Details |
| A | TRP2224-PHE2248 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255, ECO:0000269|PubMed:25043059 |
| Chain | Residue | Details |
| A | TRP2257-LEU2279 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | SITE: Important for receptor activation => ECO:0000269|PubMed:19068482 |
| Chain | Residue | Details |
| A | GLU145 | |
| A | GLU172 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN155 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | GLU1011 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | ASP1020 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | LEU1032 | |
| A | PHE1104 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000303|PubMed:7831309 |
| Chain | Residue | Details |
| A | SER1117 | |
| A | ASN1132 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 921 |
| Chain | Residue | Details |
| A | GLU1011 | proton shuttle (general acid/base) |
| A | ASP1020 | covalent catalysis |
