5TZ3

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX with [1,2,4]triazolo[1,5-a]pyrimidin-7-yl}-N-(naphthalene-2-yl)piperidine-3-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0007165	biological_process	signal transduction
C	0008081	molecular_function	phosphoric diester hydrolase activity
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0007165	biological_process	signal transduction
D	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 7OM A 1001

Chain	Residue
A	TYR655
A	ILE866
A	HOH1285
A	LEU770
A	GLN812
A	ILE826
A	PHE830
A	MET847
A	LEU858
A	GLN859
A	PHE862

---

site_id	AC2
Number of Residues	7
Details	binding site for residue ZN A 1002

Chain	Residue
A	HIS660
A	HIS696
A	ASP697
A	ASP808
A	MG1003
A	HOH1139
A	HOH1203

---

site_id	AC3
Number of Residues	7
Details	binding site for residue MG A 1003

Chain	Residue
A	ASP697
A	ZN1002
A	HOH1135
A	HOH1139
A	HOH1177
A	HOH1182
A	HOH1221

---

site_id	AC4
Number of Residues	11
Details	binding site for residue 7OM B 1001

Chain	Residue
B	TYR655
B	LEU770
B	GLN812
B	ILE826
B	PHE830
B	MET847
B	LEU858
B	GLN859
B	SER861
B	PHE862
B	HOH1280

---

site_id	AC5
Number of Residues	7
Details	binding site for residue ZN B 1002

Chain	Residue
B	HIS660
B	HIS696
B	ASP697
B	ASP808
B	MG1003
B	HOH1121
B	HOH1190

---

site_id	AC6
Number of Residues	7
Details	binding site for residue MG B 1003

Chain	Residue
B	ASP697
B	ZN1002
B	HOH1121
B	HOH1127
B	HOH1129
B	HOH1175
B	HOH1220

---

site_id	AC7
Number of Residues	12
Details	binding site for residue 7OM C 1001

Chain	Residue
C	TYR655
C	LEU809
C	GLN812
C	ILE826
C	PHE830
C	MET847
C	LEU858
C	GLN859
C	SER861
C	PHE862
C	ILE866
C	HOH1227

---

site_id	AC8
Number of Residues	6
Details	binding site for residue ZN C 1002

Chain	Residue
C	HIS660
C	HIS696
C	ASP697
C	ASP808
C	HOH1114
C	HOH1139

---

site_id	AC9
Number of Residues	6
Details	binding site for residue MG C 1003

Chain	Residue
C	ASP697
C	HOH1114
C	HOH1121
C	HOH1176
C	HOH1187
C	HOH1211

---

site_id	AD1
Number of Residues	10
Details	binding site for residue 7OM D 1001

Chain	Residue
D	TYR655
D	LEU770
D	LEU809
D	GLN812
D	ILE826
D	PHE830
D	MET847
D	LEU858
D	GLN859
D	PHE862

---

site_id	AD2
Number of Residues	7
Details	binding site for residue ZN D 1002

Chain	Residue
D	HIS660
D	HIS696
D	ASP697
D	ASP808
D	MG1003
D	HOH1122
D	HOH1168

---

site_id	AD3
Number of Residues	7
Details	binding site for residue MG D 1003

Chain	Residue
D	ASP697
D	ZN1002
D	HOH1151
D	HOH1168
D	HOH1194
D	HOH1213
D	HOH1234

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF

Chain	Residue	Details
A	HIS696-PHE707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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