5TXC

AtxE2 Isopeptidase - APO

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:23862624

Chain	Residue	Details
A	SER527
B	SER527

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:27998080

Chain	Residue	Details
A	GLU610
A	HIS638
B	GLU610
B	HIS638

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Important for activity. Binds to Astexin-3 => ECO:0000269|PubMed:27998080

Chain	Residue	Details
A	TRP116
A	ASN562
B	TRP116
B	ASN562

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Catalytically important residue that stabilizes the alkoxide intermediate. Moves to point toward the isopeptide bond => ECO:0000269|PubMed:27998080

Chain	Residue	Details
A	TYR438
B	TYR438

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