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5TWN

CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 23E A 601
ChainResidue
AALA395
AARG503
B23E601
AALA396
ALEU492
AGLY493
AVAL494
APRO495
APRO496
AARG498
AVAL499

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 602
ChainResidue
ASER84
AVAL85
AARG120

site_idAC3
Number of Residues5
Detailsbinding site for residue SO4 A 603
ChainResidue
AARG48
ALYS51
AARG158
ATHR221
ACYS223

site_idAC4
Number of Residues4
Detailsbinding site for residue SO4 A 604
ChainResidue
AHIS374
ASER476
AARG517
AMET573

site_idAC5
Number of Residues4
Detailsbinding site for residue SO4 A 605
ChainResidue
APRO496
ALEU497
AARG498
AARG570

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 A 606
ChainResidue
AGLU361
ASER371
ASER478

site_idAC7
Number of Residues4
Detailsbinding site for residue SO4 A 607
ChainResidue
ALYS79
AASP244
BLEU60
BLEU68

site_idAC8
Number of Residues17
Detailsbinding site for residue 23E B 601
ChainResidue
ATHR399
AALA400
AHIS428
A23E601
BLEU392
BALA395
BALA396
BILE424
BHIS428
BLEU492
BGLY493
BVAL494
BPRO495
BPRO496
BARG498
BVAL499
BARG503

site_idAC9
Number of Residues15
Detailsbinding site for residue 7NG B 602
ChainResidue
BARG200
BLEU204
BLEU314
BCYS316
BASP319
BVAL321
BILE363
BSER365
BCYS366
BSER368
BLEU384
BMET414
BTYR415
BTYR452
BPHE551

site_idAD1
Number of Residues4
Detailsbinding site for residue SO4 B 603
ChainResidue
BSER84
BVAL85
BGLU86
BARG120

site_idAD2
Number of Residues2
Detailsbinding site for residue SO4 B 604
ChainResidue
BGLY516
BARG517

site_idAD3
Number of Residues3
Detailsbinding site for residue SO4 B 605
ChainResidue
ASER1
BLYS379
BARG380

site_idAD4
Number of Residues2
Detailsbinding site for residue SO4 B 606
ChainResidue
BHIS475
BSER476

site_idAD5
Number of Residues3
Detailsbinding site for residue SO4 B 607
ChainResidue
BARG48
BLYS51
BCYS223

site_idAD6
Number of Residues3
Detailsbinding site for residue SO4 B 608
ChainResidue
BMET187
BGLY188
BSER189

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-07-24

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