5TW7

Crystal structure of a GMP synthase (glutamine-hydrolyzing) from Neisseria gonorrhoeae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003921	molecular_function	GMP synthase activity
A	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0046037	biological_process	GMP metabolic process
B	0003921	molecular_function	GMP synthase activity
B	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006177	biological_process	GMP biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0016874	molecular_function	ligase activity
B	0046037	biological_process	GMP metabolic process
C	0003921	molecular_function	GMP synthase activity
C	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006177	biological_process	GMP biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0016874	molecular_function	ligase activity
C	0046037	biological_process	GMP metabolic process
D	0003921	molecular_function	GMP synthase activity
D	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006177	biological_process	GMP biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0016874	molecular_function	ligase activity
D	0046037	biological_process	GMP metabolic process
E	0003921	molecular_function	GMP synthase activity
E	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006177	biological_process	GMP biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0016874	molecular_function	ligase activity
E	0046037	biological_process	GMP metabolic process
F	0003921	molecular_function	GMP synthase activity
F	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006177	biological_process	GMP biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0016874	molecular_function	ligase activity
F	0046037	biological_process	GMP metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG E 601

Chain	Residue
E	ILE497
E	VAL500
E	ILE503
E	HOH809
E	HOH818

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site_id	AC2
Number of Residues	5
Details	binding site for residue MG F 601

Chain	Residue
F	HOH851
F	ILE497
F	VAL500
F	ILE503
F	HOH796

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00344

Chain	Residue	Details
A	CYS81
B	CYS81
C	CYS81
D	CYS81
E	CYS81
F	CYS81

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site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344

Chain	Residue	Details
D	HIS171
D	GLU173
E	HIS171
E	GLU173
F	HIS171
F	GLU173
A	HIS171
A	GLU173
B	HIS171
B	GLU173
C	HIS171
C	GLU173

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00344

Chain	Residue	Details
A	SER225
B	SER225
C	SER225
D	SER225
E	SER225
F	SER225

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