Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5TVG

Crystal structure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia vietnamiensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
A	0004805	molecular_function	trehalose-phosphatase activity
A	0005829	cellular_component	cytosol
A	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
A	0005992	biological_process	trehalose biosynthetic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016758	molecular_function	hexosyltransferase activity
A	0034605	biological_process	cellular response to heat
A	0046872	molecular_function	metal ion binding
A	0070413	biological_process	trehalose metabolism in response to stress
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
B	0004805	molecular_function	trehalose-phosphatase activity
B	0005829	cellular_component	cytosol
B	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
B	0005992	biological_process	trehalose biosynthetic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016758	molecular_function	hexosyltransferase activity
B	0034605	biological_process	cellular response to heat
B	0046872	molecular_function	metal ion binding
B	0070413	biological_process	trehalose metabolism in response to stress
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
C	0004805	molecular_function	trehalose-phosphatase activity
C	0005829	cellular_component	cytosol
C	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
C	0005992	biological_process	trehalose biosynthetic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016758	molecular_function	hexosyltransferase activity
C	0034605	biological_process	cellular response to heat
C	0046872	molecular_function	metal ion binding
C	0070413	biological_process	trehalose metabolism in response to stress
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
D	0004805	molecular_function	trehalose-phosphatase activity
D	0005829	cellular_component	cytosol
D	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
D	0005992	biological_process	trehalose biosynthetic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016758	molecular_function	hexosyltransferase activity
D	0034605	biological_process	cellular response to heat
D	0046872	molecular_function	metal ion binding
D	0070413	biological_process	trehalose metabolism in response to stress
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
E	0004805	molecular_function	trehalose-phosphatase activity
E	0005829	cellular_component	cytosol
E	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
E	0005992	biological_process	trehalose biosynthetic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016758	molecular_function	hexosyltransferase activity
E	0034605	biological_process	cellular response to heat
E	0046872	molecular_function	metal ion binding
E	0070413	biological_process	trehalose metabolism in response to stress
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
F	0004805	molecular_function	trehalose-phosphatase activity
F	0005829	cellular_component	cytosol
F	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
F	0005992	biological_process	trehalose biosynthetic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016758	molecular_function	hexosyltransferase activity
F	0034605	biological_process	cellular response to heat
F	0046872	molecular_function	metal ion binding
F	0070413	biological_process	trehalose metabolism in response to stress
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
G	0004805	molecular_function	trehalose-phosphatase activity
G	0005829	cellular_component	cytosol
G	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
G	0005992	biological_process	trehalose biosynthetic process
G	0016757	molecular_function	glycosyltransferase activity
G	0016758	molecular_function	hexosyltransferase activity
G	0034605	biological_process	cellular response to heat
G	0046872	molecular_function	metal ion binding
G	0070413	biological_process	trehalose metabolism in response to stress
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
H	0004805	molecular_function	trehalose-phosphatase activity
H	0005829	cellular_component	cytosol
H	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
H	0005992	biological_process	trehalose biosynthetic process
H	0016757	molecular_function	glycosyltransferase activity
H	0016758	molecular_function	hexosyltransferase activity
H	0034605	biological_process	cellular response to heat
H	0046872	molecular_function	metal ion binding
H	0070413	biological_process	trehalose metabolism in response to stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue UDP A 501

Chain	Residue
A	VAL263
A	VAL369
A	GLU372
A	GOL504
A	HOH621
A	HOH623
A	HOH665
A	HOH673
A	ARG265
A	LYS270
A	PRO300
A	LYS341
A	ARG344
A	LEU347
A	ASN367
A	LEU368

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 502

Chain	Residue
A	TYR92
A	LEU362
A	ARG363
A	PHE390
A	TYR406
A	HOH735
B	SER94
B	ASP163

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 503

Chain	Residue
A	PRO19
A	VAL229
A	TYR230
A	ILE234
A	ARG344

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 504

Chain	Residue
A	HIS156
A	ASP364
A	GLY365
A	MET366
A	ASN367
A	UDP501
A	HOH614
A	HOH748

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL A 505

Chain	Residue
A	GLN34
A	ASP447
A	ARG454
A	HOH637

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL A 506

Chain	Residue
A	MET282
A	GLY285
A	ALA286
A	ASP413

site_id	AC7
Number of Residues	6
Details	binding site for residue MG A 507

Chain	Residue
A	PHE351
A	ARG352
A	SER354
A	GLN377
A	HOH699
A	HOH738

site_id	AC8
Number of Residues	13
Details	binding site for residue UDP B 501

Chain	Residue
B	VAL263
B	ARG265
B	LYS270
B	TYR342
B	ARG344
B	LEU347
B	LEU368
B	VAL369
B	GLU372
B	GOL502
B	HOH630
B	HOH647
B	HOH706

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL B 502

Chain	Residue
B	HIS156
B	ASP364
B	GLY365
B	MET366
B	ASN367
B	UDP501
B	HOH635

site_id	AD1
Number of Residues	5
Details	binding site for residue MG B 503

Chain	Residue
B	ARG352
B	SER354
B	GLN377
B	HOH656
B	HOH688

site_id	AD2
Number of Residues	16
Details	binding site for residue UDP C 501

Chain	Residue
C	VAL263
C	ARG265
C	LYS270
C	TYR342
C	ARG344
C	LEU347
C	ASN367
C	LEU368
C	VAL369
C	GLU372
C	GOL502
C	HOH608
C	HOH632
C	HOH634
C	HOH635
C	HOH657

site_id	AD3
Number of Residues	7
Details	binding site for residue GOL C 502

Chain	Residue
C	ASP364
C	GLY365
C	MET366
C	ASN367
C	LEU368
C	UDP501
C	HOH603

site_id	AD4
Number of Residues	15
Details	binding site for residue UDP D 501

Chain	Residue
D	VAL263
D	ARG265
D	LYS270
D	LYS341
D	TYR342
D	ARG344
D	LEU347
D	LEU368
D	VAL369
D	GLU372
D	GOL502
D	HOH604
D	HOH611
D	HOH621
D	HOH657

site_id	AD5
Number of Residues	8
Details	binding site for residue GOL D 502

Chain	Residue
D	HIS156
D	ASP364
D	GLY365
D	MET366
D	ASN367
D	LEU368
D	UDP501
D	HOH633

site_id	AD6
Number of Residues	3
Details	binding site for residue GOL D 503

Chain	Residue
D	ARG265
D	THR302
D	ARG303

site_id	AD7
Number of Residues	5
Details	binding site for residue MG D 504

Chain	Residue
D	ARG352
D	SER354
D	GLN377
D	HOH610
D	HOH635

site_id	AD8
Number of Residues	14
Details	binding site for residue UDP E 501

Chain	Residue
E	VAL263
E	ARG265
E	LYS270
E	TYR342
E	ARG344
E	LEU347
E	ASN367
E	LEU368
E	VAL369
E	GLU372
E	GOL502
E	HOH613
E	HOH626
E	HOH629

site_id	AD9
Number of Residues	7
Details	binding site for residue GOL E 502

Chain	Residue
E	ASP364
E	GLY365
E	MET366
E	ASN367
E	LEU368
E	UDP501
E	HOH606

site_id	AE1
Number of Residues	14
Details	binding site for residue UDP F 501

Chain	Residue
F	VAL263
F	ARG265
F	LYS270
F	TYR342
F	ARG344
F	LEU347
F	LEU368
F	VAL369
F	GLU372
F	GOL502
F	HOH615
F	HOH638
F	HOH658
F	HOH660

site_id	AE2
Number of Residues	7
Details	binding site for residue GOL F 502

Chain	Residue
F	ASP364
F	GLY365
F	MET366
F	ASN367
F	LEU368
F	UDP501
F	HOH605

site_id	AE3
Number of Residues	13
Details	binding site for residue UDP G 501

Chain	Residue
G	VAL263
G	ARG265
G	LYS270
G	LYS341
G	TYR342
G	ARG344
G	LEU347
G	ASN367
G	LEU368
G	VAL369
G	GLU372
G	GOL502
G	HOH606

site_id	AE4
Number of Residues	6
Details	binding site for residue GOL G 502

Chain	Residue
G	ASP364
G	GLY365
G	MET366
G	ASN367
G	UDP501
G	HOH605

site_id	AE5
Number of Residues	11
Details	binding site for residue UDP H 501

Chain	Residue
H	VAL263
H	ARG265
H	LYS270
H	LYS341
H	TYR342
H	ASN367
H	LEU368
H	VAL369
H	GLU372
H	GOL502
H	HOH607

site_id	AE6
Number of Residues	7
Details	binding site for residue GOL H 502

Chain	Residue
H	TRP87
H	HIS156
H	ASP364
H	GLY365
H	MET366
H	ASN367
H	UDP501

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)