Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003911 | molecular_function | DNA ligase (NAD+) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006260 | biological_process | DNA replication |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | binding site for residue NAD A 701 |
| Chain | Residue |
| A | HIS18 |
| A | SER81 |
| A | LEU82 |
| A | GLU113 |
| A | LEU114 |
| A | MET115 |
| A | LEU116 |
| A | ALA120 |
| A | ARG136 |
| A | GLU173 |
| A | TYR225 |
| A | TYR22 |
| A | VAL288 |
| A | LYS290 |
| A | LYS314 |
| A | MG703 |
| A | HOH900 |
| A | HOH905 |
| A | HOH949 |
| A | HOH958 |
| A | HOH968 |
| A | HOH969 |
| A | HIS23 |
| A | HOH1031 |
| A | HOH1041 |
| A | HOH1083 |
| A | HOH1182 |
| A | HOH1275 |
| A | PRO28 |
| A | ILE30 |
| A | ASP32 |
| A | TYR35 |
| A | ASP36 |
| A | LEU80 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 702 |
| Chain | Residue |
| A | CYS408 |
| A | CYS411 |
| A | CYS426 |
| A | CYS432 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 703 |
| Chain | Residue |
| A | NAD701 |
| A | HOH905 |
| A | HOH949 |
| A | HOH958 |
| A | HOH962 |
| A | HOH1182 |
Functional Information from PROSITE/UniProt
| site_id | PS01056 |
| Number of Residues | 16 |
| Details | DNA_LIGASE_N2 NAD-dependent DNA ligase signature 2. VGRTGaITpVarLePV |
| Chain | Residue | Details |
| A | VAL331-VAL346 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | Region: {"description":"Interaction with target DNA","evidences":[{"source":"PubMed","id":"17466627","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11781321","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17466627","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17466627","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with target DNA","evidences":[{"source":"PubMed","id":"17466627","evidenceCode":"ECO:0000305"}]} |
