5TRT

Crystal Structure of enoyl-(acyl carrier protein) reductase from Burkholderia pseudomallei 1710b bound to NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
B	0000166	molecular_function	nucleotide binding
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
C	0000166	molecular_function	nucleotide binding
C	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
D	0000166	molecular_function	nucleotide binding
D	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue EDO A 301

Chain	Residue
A	GLU223
A	HOH491
D	HOH538

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 302

Chain	Residue
A	GLU58
A	VAL60
A	HIS81
A	HOH556

---

site_id	AC3
Number of Residues	25
Details	binding site for residue NAD A 303

Chain	Residue
A	ILE20
A	VAL40
A	CYS63
A	ASP64
A	VAL65
A	SER91
A	ILE92
A	GLY93
A	LEU144
A	SER145
A	LYS163
A	ALA189
A	GLY190
A	PRO191
A	ILE192
A	HOH414
A	HOH426
A	HOH433
A	HOH437
A	HOH480
A	HOH511
A	HOH552
A	HOH558
A	GLY13
A	LEU15

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 304

Chain	Residue
A	ALA76
A	GLU98
A	PRO133
A	HOH404
A	HOH584

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO B 301

Chain	Residue
A	ARG110
B	ALA66
B	ASP67
B	ASP68
B	HOH411
B	HOH494

---

site_id	AC6
Number of Residues	27
Details	binding site for residue NAD B 302

Chain	Residue
B	GLY13
B	LEU15
B	SER19
B	ILE20
B	VAL40
B	CYS63
B	ASP64
B	VAL65
B	SER91
B	ILE92
B	GLY93
B	LEU144
B	SER145
B	TYR146
B	LYS163
B	ALA189
B	GLY190
B	PRO191
B	ILE192
B	EDO303
B	HOH410
B	HOH413
B	HOH420
B	HOH431
B	HOH460
B	HOH471
B	HOH481

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO B 303

Chain	Residue
B	TYR156
B	NAD302
B	HOH410
B	HOH423

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO C 301

Chain	Residue
C	ALA66
C	ASP68
C	HOH425
C	HOH533
D	ARG110

---

site_id	AC9
Number of Residues	21
Details	binding site for residue NAD C 302

Chain	Residue
C	HOH431
C	GLY13
C	LEU15
C	SER19
C	ILE20
C	VAL40
C	ASP64
C	VAL65
C	SER91
C	ILE92
C	GLY93
C	LEU144
C	SER145
C	LYS163
C	ALA189
C	GLY190
C	PRO191
C	ILE192
C	HOH409
C	HOH415
C	HOH418

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO D 301

Chain	Residue
C	ARG110
D	ALA66
D	ASP68
D	HOH422

---

site_id	AD2
Number of Residues	22
Details	binding site for residue NAD D 302

Chain	Residue
D	GLY13
D	LEU15
D	ILE20
D	VAL40
D	CYS63
D	ASP64
D	VAL65
D	SER91
D	ILE92
D	GLY93
D	ILE119
D	LEU144
D	SER145
D	LYS163
D	ALA189
D	GLY190
D	PRO191
D	ILE192
D	HOH420
D	HOH423
D	HOH456
D	HOH463

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO D 303

Chain	Residue
A	ASN252
A	HOH458
D	GLU150
D	HOH449

---

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO D 304

Chain	Residue
A	HOH438
D	ASN252
D	HOH416
D	HOH430
D	HOH453

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