5TQX
CryoEM reconstruction of human IKK1, intermediate conformation 2
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGGFGNVClYqhreldlk..........IAIK |
| Chain | Residue | Details |
| A | LEU21-LYS44 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpeNIVL |
| Chain | Residue | Details |
| A | ILE140-LEU152 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP144 | |
| B | ASP144 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU21 | |
| A | LYS44 | |
| B | LEU21 | |
| B | LYS44 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKB/AKT1 and SGK1 => ECO:0000269|PubMed:10485710, ECO:0000269|PubMed:19088076 |
| Chain | Residue | Details |
| A | THR23 | |
| B | THR23 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAP3K14 => ECO:0000269|PubMed:9520446 |
| Chain | Residue | Details |
| A | GLU176 | |
| B | GLU176 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:17116858 |
| Chain | Residue | Details |
| A | THR179 | |
| B | THR179 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:19088076 |
| Chain | Residue | Details |
| A | GLU180 | |
| B | GLU180 |
