5TNU
S. tokodaii XPB II crystal structure at 3.0 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| A | 0120545 | molecular_function | nucleic acid conformation isomerase activity |
| A | 0140097 | molecular_function | catalytic activity, acting on DNA |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006281 | biological_process | DNA repair |
| B | 0006974 | biological_process | DNA damage response |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| B | 0120545 | molecular_function | nucleic acid conformation isomerase activity |
| B | 0140097 | molecular_function | catalytic activity, acting on DNA |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | THR92 |
| A | GLY93 |
| A | ALA94 |
| A | GLY95 |
| A | LYS96 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | TYR131 |
| A | GLY95 |
| A | THR97 |
| A | GLN98 |
| A | ARG127 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | ARG70 |
| A | ARG253 |
| A | LEU257 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | LYS64 |
| A | LYS66 |
| A | ASP133 |
| A | GLN189 |
| A | LEU212 |
| A | ILE215 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | GLY140 |
| A | GLY142 |
| A | GLU143 |
| B | ASP155 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | ARG258 |
| A | TRP298 |
| A | ALA429 |
| A | ARG432 |
| A | ARG436 |
| A | ARG437 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | TYR254 |
| A | ARG258 |
| A | GLY427 |
| A | ARG432 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 508 |
| Chain | Residue |
| A | THR117 |
| A | ILE118 |
| B | THR117 |
| B | ILE118 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 509 |
| Chain | Residue |
| A | ARG127 |
| A | LYS130 |
| A | TYR131 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 510 |
| Chain | Residue |
| A | ARG436 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 511 |
| Chain | Residue |
| A | SER181 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 512 |
| Chain | Residue |
| A | GLU182 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 513 |
| Chain | Residue |
| A | LYS8 |
| A | ILE63 |
| A | GLU162 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 514 |
| Chain | Residue |
| A | GLU25 |
| A | SER105 |
| A | LYS108 |
| A | HOH602 |
| A | HOH614 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 515 |
| Chain | Residue |
| A | TYR16 |
| A | GLY19 |
| A | ASN248 |
| A | GLU249 |
| A | HOH613 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 516 |
| Chain | Residue |
| A | TYR237 |
| A | ILE239 |
| A | LYS283 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 517 |
| Chain | Residue |
| A | ASN129 |
| A | ASP133 |
| A | GLU182 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 518 |
| Chain | Residue |
| A | ARG37 |
| A | LYS41 |
| A | GLU83 |
| A | HOH649 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| B | THR92 |
| B | GLY93 |
| B | ALA94 |
| B | GLY95 |
| B | LYS96 |
| B | THR97 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | LYS64 |
| B | LYS66 |
| B | ASP133 |
| B | GLN189 |
| B | LEU212 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| A | ASP155 |
| B | GLY140 |
| B | GLY141 |
| B | GLY142 |
| B | GLU143 |
| B | SER156 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| B | GLN98 |
| B | ARG127 |
| B | TYR131 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 505 |
| Chain | Residue |
| B | ILE63 |
| B | LYS108 |
| B | LEU190 |
| B | HOH621 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 506 |
| Chain | Residue |
| B | SER181 |
| B | ARG205 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 508 |
| Chain | Residue |
| B | HOH614 |
| A | ASP56 |
| A | LEU58 |
| A | LEU146 |
| A | LYS167 |
| B | LEU146 |
| B | GLU163 |
| B | LYS167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 288 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 128 |
| Details | Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 106 |
| Details | Region: {"description":"DRD domain","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Region: {"description":"Flexible hinge region","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 59 |
| Details | Region: {"description":"ThM region","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Motif: {"description":"RED motif","evidences":[{"source":"PubMed","id":"32374860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Site: {"description":"Wedge residue","evidences":[{"source":"PubMed","id":"32986831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
