5TNL
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted (S)-1,2-Epoxyhexane hydrolysis intermediate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004301 | molecular_function | epoxide hydrolase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0043657 | cellular_component | host cell |
| B | 0004301 | molecular_function | epoxide hydrolase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0043657 | cellular_component | host cell |
| C | 0004301 | molecular_function | epoxide hydrolase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0043657 | cellular_component | host cell |
| D | 0004301 | molecular_function | epoxide hydrolase activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0043657 | cellular_component | host cell |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue 7FB A 401 |
| Chain | Residue |
| A | HIS177 |
| A | PHE178 |
| A | HIS207 |
| A | TYR239 |
| A | HIS297 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue 7FB B 401 |
| Chain | Residue |
| B | HIS297 |
| B | HIS177 |
| B | PHE178 |
| B | HIS207 |
| B | TYR239 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue 7FB C 401 |
| Chain | Residue |
| C | HIS177 |
| C | PHE178 |
| C | HIS207 |
| C | TYR239 |
| C | HIS297 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue 7FB D 401 |
| Chain | Residue |
| D | HIS177 |
| D | PHE178 |
| D | HIS207 |
| D | TYR239 |
| D | HIS297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 440 |
| Details | Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile; hydroxyalkyl-enzyme intermediate","evidences":[{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27980032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20118260","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21933119","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26136396","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4DNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JYC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"20118260","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21933119","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26136396","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20118260","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21933119","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26136396","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27980032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392259","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EUS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JYC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
