5TNJ

Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 4-Vinyl-1-cyclohexene 1,2-epoxide hydrolysis intermediate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
B	0016787	molecular_function	hydrolase activity
C	0016787	molecular_function	hydrolase activity
D	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue AVH A 401

Chain	Residue
A	ASP129
A	VAL175
A	HIS177
A	PHE178
A	TYR239
A	MET272
A	HIS297
A	8MD402

---

site_id	AC2
Number of Residues	6
Details	binding site for residue 8MD A 402

Chain	Residue
A	HIS177
A	TYR239
A	HIS297
A	AVH401
A	HOH510
A	ASP129

---

site_id	AC3
Number of Residues	15
Details	binding site for Di-peptide BVH B 401 and ASP B 129

Chain	Residue
B	PHE63
B	HIS128
B	ILE130
B	GLY131
B	ILE132
B	MET152
B	GLN153
B	ALA154
B	LEU174
B	HIS177
B	PHE178
B	TYR239
B	HIS297
B	DVH402
B	HOH637

---

site_id	AC4
Number of Residues	15
Details	binding site for Di-peptide BVH B 401 and ASP B 129

Chain	Residue
B	PHE63
B	HIS128
B	ILE130
B	GLY131
B	ILE132
B	MET152
B	GLN153
B	ALA154
B	LEU174
B	HIS177
B	PHE178
B	TYR239
B	HIS297
B	DVH402
B	HOH637

---

site_id	AC5
Number of Residues	16
Details	binding site for Di-peptide DVH B 402 and ASP B 129

Chain	Residue
B	PHE63
B	HIS128
B	ILE130
B	GLY131
B	ILE132
B	MET152
B	GLN153
B	ALA154
B	PRO155
B	VAL175
B	HIS177
B	TYR239
B	MET272
B	HIS297
B	BVH401
B	HOH637

---

site_id	AC6
Number of Residues	16
Details	binding site for Di-peptide DVH B 402 and ASP B 129

Chain	Residue
B	PHE63
B	HIS128
B	ILE130
B	GLY131
B	ILE132
B	MET152
B	GLN153
B	ALA154
B	PRO155
B	VAL175
B	HIS177
B	TYR239
B	MET272
B	HIS297
B	BVH401
B	HOH637

---

site_id	AC7
Number of Residues	17
Details	binding site for Di-peptide BVH C 401 and ASP C 129

Chain	Residue
C	PHE63
C	HIS128
C	ILE130
C	GLY131
C	ILE132
C	MET152
C	GLN153
C	ALA154
C	LEU174
C	VAL175
C	HIS177
C	PHE178
C	TYR239
C	HIS297
C	DVH402
C	HOH518
C	HOH650

---

site_id	AC8
Number of Residues	17
Details	binding site for Di-peptide BVH C 401 and ASP C 129

Chain	Residue
C	GLN153
C	ALA154
C	LEU174
C	VAL175
C	HIS177
C	PHE178
C	TYR239
C	HIS297
C	DVH402
C	HOH518
C	HOH650
C	PHE63
C	HIS128
C	ILE130
C	GLY131
C	ILE132
C	MET152

---

site_id	AC9
Number of Residues	16
Details	binding site for Di-peptide DVH C 402 and ASP C 129

Chain	Residue
C	PHE63
C	HIS128
C	ILE130
C	GLY131
C	ILE132
C	MET152
C	GLN153
C	ALA154
C	PRO155
C	VAL175
C	HIS177
C	TYR239
C	MET272
C	HIS297
C	BVH401
C	HOH650

---

site_id	AD1
Number of Residues	16
Details	binding site for Di-peptide DVH C 402 and ASP C 129

Chain	Residue
C	PHE63
C	HIS128
C	ILE130
C	GLY131
C	ILE132
C	MET152
C	GLN153
C	ALA154
C	PRO155
C	VAL175
C	HIS177
C	TYR239
C	MET272
C	HIS297
C	BVH401
C	HOH650

---

site_id	AD2
Number of Residues	15
Details	binding site for Di-peptide BVH D 401 and ASP D 129

Chain	Residue
D	PHE63
D	HIS128
D	ILE130
D	GLY131
D	ILE132
D	MET152
D	GLN153
D	ALA154
D	LEU174
D	HIS177
D	PHE178
D	TYR239
D	HIS297
D	DVH402
D	HOH644

---

site_id	AD3
Number of Residues	15
Details	binding site for Di-peptide BVH D 401 and ASP D 129

Chain	Residue
D	PHE63
D	HIS128
D	ILE130
D	GLY131
D	ILE132
D	MET152
D	GLN153
D	ALA154
D	LEU174
D	HIS177
D	PHE178
D	TYR239
D	HIS297
D	DVH402
D	HOH644

---

site_id	AD4
Number of Residues	16
Details	binding site for Di-peptide DVH D 402 and ASP D 129

Chain	Residue
D	PHE63
D	HIS128
D	ILE130
D	GLY131
D	ILE132
D	MET152
D	GLN153
D	ALA154
D	PRO155
D	VAL175
D	HIS177
D	TYR239
D	MET272
D	HIS297
D	BVH401
D	HOH644

---

site_id	AD5
Number of Residues	16
Details	binding site for Di-peptide DVH D 402 and ASP D 129

Chain	Residue
D	PHE63
D	HIS128
D	ILE130
D	GLY131
D	ILE132
D	MET152
D	GLN153
D	ALA154
D	PRO155
D	VAL175
D	HIS177
D	TYR239
D	MET272
D	HIS297
D	BVH401
D	HOH644

---