5TN5
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the AC-ring estrogen, (1S,3aS,5S,7aS)-5-(4-hydroxyphenyl)-7a-methyloctahydro-1H-inden-1-ol
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue 7G0 A 601 |
| Chain | Residue |
| A | MET343 |
| A | LEU346 |
| A | GLU353 |
| A | LEU387 |
| A | ARG394 |
| A | PHE404 |
| A | HIS524 |
| A | LEU525 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 7G0 B 601 |
| Chain | Residue |
| B | GLU353 |
| B | LEU387 |
| B | ARG394 |
| B | HIS524 |
| B | LEU525 |
| B | HOH720 |
| B | LEU346 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | SER537 | |
| B | SER537 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 |
