5TMZ
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the estradiol derivative, (8S,9S,13S,14S,17S)-16-(3-methoxybenzyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 7FQ A 601 |
| Chain | Residue |
| A | MET343 |
| A | HOH721 |
| A | LEU346 |
| A | GLU353 |
| A | LEU387 |
| A | ARG394 |
| A | MET421 |
| A | HIS524 |
| A | LEU525 |
| A | MET528 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 7FQ B 601 |
| Chain | Residue |
| B | MET343 |
| B | LEU346 |
| B | ALA350 |
| B | GLU353 |
| B | LEU387 |
| B | MET388 |
| B | LEU391 |
| B | ARG394 |
| B | MET421 |
| B | ILE424 |
| B | HIS524 |
| B | MET528 |
| B | HOH728 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | SER537 | |
| B | SER537 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 | |
