5TMH

Structure of Zika virus NS5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004483	molecular_function	methyltransferase cap1 activity
A	0005524	molecular_function	ATP binding
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
A	0039694	biological_process	viral RNA genome replication
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0004483	molecular_function	methyltransferase cap1 activity
B	0005524	molecular_function	ATP binding
B	0008168	molecular_function	methyltransferase activity
B	0032259	biological_process	methylation
B	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue SAH A 1001

Chain	Residue
A	SER56
A	ASP131
A	VAL132
A	PHE133
A	ASP146
A	GLY58
A	GLY81
A	CYS82
A	GLY86
A	TRP87
A	LYS105
A	HIS110
A	VAL130

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	GLU439
A	HIS443
A	CYS448
A	CYS451

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1003

Chain	Residue
A	HIS714
A	ASN716
A	CYS730
A	CYS849

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 1004

Chain	Residue
A	ARG473
A	GLY538
A	LYS691

---

site_id	AC5
Number of Residues	2
Details	binding site for residue GOL A 1005

Chain	Residue
A	GLU149
A	ARG160

---

site_id	AC6
Number of Residues	13
Details	binding site for residue SAH B 1001

Chain	Residue
B	SER56
B	GLY58
B	GLY81
B	CYS82
B	TRP87
B	THR104
B	LYS105
B	HIS110
B	VAL130
B	ASP131
B	VAL132
B	PHE133
B	ASP146

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 1002

Chain	Residue
B	GLU439
B	HIS443
B	CYS448
B	CYS451

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 1003

Chain	Residue
B	HIS714
B	ASN716
B	CYS730
B	CYS849

---

site_id	AC9
Number of Residues	2
Details	binding site for residue SO4 B 1004

Chain	Residue
B	ARG473
B	GLY538

---

site_id	AD1
Number of Residues	1
Details	binding site for residue GOL B 1005

Chain	Residue
B	LYS29

---

site_id	AD2
Number of Residues	1
Details	binding site for residue GOL B 1006

Chain	Residue
B	ARG160

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	300
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27386922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27399257","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29080786","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Region: {"description":"SUMO-interacting motif (SIM)","evidences":[{"source":"UniProtKB","id":"A0A024B7W1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Motif: {"description":"Nuclear localization signal (NLS)","evidences":[{"source":"PubMed","id":"30848123","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Active site: {"description":"For 2'-O-MTase activity","evidences":[{"source":"UniProtKB","id":"Q6YMS4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"A0A024B7W1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28291746","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345656","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	Site: {"description":"Essential for 2'-O-methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Site: {"description":"Essential for 2'-O-methyltransferase and N-7 methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03314","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---