5TM4
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC Analog, 5-(4-((1R,4S,6R)-6-((3-chlorophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenoxy)pentanoic acid
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 7E3 A 601 |
| Chain | Residue |
| A | TYR331 |
| A | LEU410 |
| A | GLN414 |
| A | 7E3602 |
| A | ASP332 |
| A | ARG335 |
| A | PRO336 |
| A | PHE337 |
| A | SER338 |
| A | SER341 |
| A | MET342 |
| A | ASN407 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue 7E3 A 602 |
| Chain | Residue |
| A | PHE337 |
| A | GLN414 |
| A | 7E3601 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue 7E3 A 603 |
| Chain | Residue |
| A | MET343 |
| A | THR347 |
| A | GLU353 |
| A | LEU387 |
| A | MET388 |
| A | ARG394 |
| A | PHE404 |
| A | GLU419 |
| A | GLY420 |
| A | MET421 |
| A | ILE424 |
| A | GLY521 |
| A | HIS524 |
| A | LEU525 |
| A | MET528 |
| A | LEU540 |
| A | HOH732 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue 7E3 B 601 |
| Chain | Residue |
| B | MET343 |
| B | THR347 |
| B | ALA350 |
| B | GLU353 |
| B | LEU387 |
| B | MET388 |
| B | ARG394 |
| B | VAL418 |
| B | MET421 |
| B | ILE424 |
| B | GLY521 |
| B | HIS524 |
| B | SER537 |
| B | LEU540 |
| B | LEU541 |
| B | HOH736 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 130 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | ILE358-GLU423 | |
| B | ILE358-GLU423 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 88 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | ILE358-LEU378 | |
| A | ARG394-VAL418 | |
| B | ILE358-LEU378 | |
| B | ARG394-VAL418 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:7838153 |
| Chain | Residue | Details |
| A | ALA340 | |
| B | ALA340 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420 |
| Chain | Residue | Details |
| A | SER433 | |
| B | SER433 |
