5TLD

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the phenylamino-substituted estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 6WV A 601

Chain	Residue
A	MET343
A	GLU353
A	LEU387
A	ARG394
A	GLU419
A	MET421
A	HIS524
A	HOH730

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site_id	AC2
Number of Residues	7
Details	binding site for residue 6WV B 601

Chain	Residue
B	LEU387
B	MET388
B	ARG394
B	MET421
B	HIS524
B	HOH713
B	GLU353

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	ILE358-GLU423
B	ILE358-GLU423

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site_id	SWS_FT_FI2
Number of Residues	88
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	ILE358-LEU378
A	ARG394-VAL418
B	ILE358-LEU378
B	ARG394-VAL418

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE

Chain	Residue	Details
A	TYR526
B	TYR526

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:7838153

Chain	Residue	Details
A	ALA340
B	ALA340

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420

Chain	Residue	Details
A	SER433
B	SER433

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