5TKP
Crystal structure of FBP aldolase from Toxoplasma gondii, equilibrium Schiff base FBP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003779 | molecular_function | actin binding |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue P6F A 401 |
| Chain | Residue |
| A | ALA32 |
| A | SER273 |
| A | GLY274 |
| A | SER301 |
| A | TYR302 |
| A | GLY303 |
| A | ARG304 |
| A | HOH512 |
| A | HOH519 |
| A | HOH526 |
| A | HOH584 |
| A | ASP34 |
| A | HOH601 |
| A | HOH614 |
| A | SER36 |
| A | THR39 |
| A | LYS107 |
| A | LYS146 |
| A | ARG148 |
| A | GLU189 |
| A | LYS231 |
Functional Information from PROSITE/UniProt
| site_id | PS00158 |
| Number of Residues | 11 |
| Details | ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VlLEGaLLKPN |
| Chain | Residue | Details |
| A | VAL223-ASN233 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000303|PubMed:28972169 |
| Chain | Residue | Details |
| A | GLU189 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Schiff-base intermediate with dihydroxyacetone phosphate => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3, ECO:0007744|PDB:5TKC |
| Chain | Residue | Details |
| A | LYS231 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3, ECO:0007744|PDB:5TKC, ECO:0007744|PDB:5TKL |
| Chain | Residue | Details |
| A | ASP34 | |
| A | SER36 | |
| A | SER273 | |
| A | GLY274 | |
| A | GLY303 | |
| A | ARG304 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TKC, ECO:0007744|PDB:5TKL |
| Chain | Residue | Details |
| A | THR39 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00883 |
| Chain | Residue | Details |
| A | ARG43 | |
| A | SER301 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3, ECO:0007744|PDB:5TKC |
| Chain | Residue | Details |
| A | LYS107 | |
| A | GLU189 | |
| A | LYS231 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3 |
| Chain | Residue | Details |
| A | LYS146 |
