5TK3

Crystal structure of FBP aldolase from Toxoplasma gondii, burst-phase ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005737	cellular_component	cytoplasm
A	0006096	biological_process	glycolytic process
A	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue 13P A 401

Chain	Residue
A	ALA32
A	G3H402
A	HOH501
A	HOH508
A	HOH511
A	HOH528
A	HOH551
A	HOH611
A	HOH635
A	HOH644
A	HOH733
A	ASP34
A	LYS146
A	LYS231
A	SER273
A	GLY274
A	SER301
A	GLY303
A	ARG304

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site_id	AC2
Number of Residues	19
Details	binding site for residue G3H A 402

Chain	Residue
A	SER36
A	THR39
A	LYS107
A	LYS146
A	ARG148
A	GLU189
A	13P401
A	GOL403
A	HOH502
A	HOH511
A	HOH514
A	HOH523
A	HOH528
A	HOH551
A	HOH605
A	HOH627
A	HOH649
A	HOH724
A	HOH735

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site_id	AC3
Number of Residues	10
Details	binding site for residue GOL A 403

Chain	Residue
A	GLU35
A	SER36
A	THR39
A	LYS107
A	ARG148
A	G3H402
A	HOH502
A	HOH514
A	HOH605
A	HOH649

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Functional Information from PROSITE/UniProt

site_id	PS00158
Number of Residues	11
Details	ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VlLEGaLLKPN

Chain	Residue	Details
A	VAL223-ASN233

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000303|PubMed:28972169

Chain	Residue	Details
A	GLU189

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with dihydroxyacetone phosphate => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3, ECO:0007744|PDB:5TKC

Chain	Residue	Details
A	LYS231

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3, ECO:0007744|PDB:5TKC, ECO:0007744|PDB:5TKL

Chain	Residue	Details
A	ASP34
A	SER36
A	SER273
A	GLY274
A	GLY303
A	ARG304

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TKC, ECO:0007744|PDB:5TKL

Chain	Residue	Details
A	THR39

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site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00883

Chain	Residue	Details
A	ARG43
A	SER301

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3, ECO:0007744|PDB:5TKC

Chain	Residue	Details
A	LYS107
A	GLU189
A	LYS231

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3

Chain	Residue	Details
A	LYS146

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