5TJR

X-ray Crystal structure of a methylmalonate semialdehyde dehydrogenase from Pseudomonas sp. AAC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0004491	molecular_function	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue ADP A 501

Chain	Residue
A	THR146
A	TYR231
A	PRO147
A	PHE148
A	LYS172
A	GLU175
A	ASP204
A	LYS205
A	SER225
A	ILE228

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site_id	AC2
Number of Residues	10
Details	binding site for residue ADP B 501

Chain	Residue
B	THR146
B	PHE148
B	ASN149
B	LYS172
B	PRO173
B	GLU175
B	VAL208
B	GLY224
B	SER225
B	ILE228

---

site_id	AC3
Number of Residues	11
Details	binding site for residue ADP D 501

Chain	Residue
D	ILE145
D	THR146
D	PRO147
D	PHE148
D	LYS172
D	PRO173
D	GLU175
D	ARG176
D	LYS205
D	SER225
D	ILE228

---

site_id	AC4
Number of Residues	11
Details	binding site for residue ADP E 501

Chain	Residue
E	THR146
E	PRO147
E	PHE148
E	ASN149
E	LYS172
E	SER174
E	GLU175
E	LYS205
E	VAL208
E	SER225
E	ILE228

---

site_id	AC5
Number of Residues	12
Details	binding site for residue ADP F 501

Chain	Residue
F	THR146
F	PHE148
F	LYS172
F	PRO173
F	SER174
F	GLU175
F	ARG176
F	LYS205
F	VAL208
F	PHE222
F	SER225
F	ILE228

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Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YgSCGERCMAIS

Chain	Residue	Details
A	TYR273-SER284

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