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5TI6

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 8841881

Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 7CO A 201
ChainResidue
ATRP81
AHOH365
AHOH391
APRO82
ALEU92
ALYS99
AILE100
AASN140
AILE146
AHOH314
AHOH338

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO A 203
ChainResidue
ASER42
AMET43
AASN162
AHOH325
AHOH409

site_idAC4
Number of Residues4
Detailsbinding site for residue EDO A 204
ChainResidue
ATYR137
AILE138
ALYS160
AGLU163

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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