Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5THP

Rhodocetin in complex with the integrin alpha2-A domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
B	0005576	cellular_component	extracellular region
B	0035821	biological_process	modulation of process of another organism
B	0090729	molecular_function	toxin activity
D	0005576	cellular_component	extracellular region
D	0035821	biological_process	modulation of process of another organism
D	0090729	molecular_function	toxin activity
E	0005576	cellular_component	extracellular region
E	0035821	biological_process	modulation of process of another organism
E	0090729	molecular_function	toxin activity
G	0005576	cellular_component	extracellular region
G	0035821	biological_process	modulation of process of another organism
G	0090729	molecular_function	toxin activity
H	0005576	cellular_component	extracellular region
H	0035821	biological_process	modulation of process of another organism
H	0090729	molecular_function	toxin activity
J	0005576	cellular_component	extracellular region
J	0035821	biological_process	modulation of process of another organism
J	0090729	molecular_function	toxin activity
K	0005576	cellular_component	extracellular region
K	0035821	biological_process	modulation of process of another organism
K	0090729	molecular_function	toxin activity
M	0005576	cellular_component	extracellular region
M	0035821	biological_process	modulation of process of another organism
M	0090729	molecular_function	toxin activity
N	0005576	cellular_component	extracellular region
N	0035821	biological_process	modulation of process of another organism
N	0090729	molecular_function	toxin activity
P	0005576	cellular_component	extracellular region
P	0035821	biological_process	modulation of process of another organism
P	0090729	molecular_function	toxin activity
Q	0005576	cellular_component	extracellular region
Q	0035821	biological_process	modulation of process of another organism
Q	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue NA A 201

Chain	Residue
A	GLU27
A	HOH316

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 202

Chain	Residue
A	GLN55
A	HOH310
I	TYR258
I	HOH514

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 203

Chain	Residue
I	HIS287
A	TYR11
A	SER46
A	HOH312

site_id	AC4
Number of Residues	1
Details	binding site for residue NA B 201

Chain	Residue
B	GLU18

site_id	AC5
Number of Residues	2
Details	binding site for residue NA C 401

Chain	Residue
C	ASN303
O	THR337

site_id	AC6
Number of Residues	2
Details	binding site for residue NA C 402

Chain	Residue
C	GLU285
C	ASP321

site_id	AC7
Number of Residues	1
Details	binding site for residue NA C 403

Chain	Residue
C	HIS287

site_id	AC8
Number of Residues	6
Details	binding site for residue MG C 404

Chain	Residue
C	ASP180
C	SER182
C	SER184
C	THR250
C	ASP283
C	HOH503

site_id	AC9
Number of Residues	2
Details	binding site for residue CL C 405

Chain	Residue
C	SER334
C	ILE335

site_id	AD1
Number of Residues	2
Details	binding site for residue CL C 406

Chain	Residue
C	TRP188
C	ASP189

site_id	AD2
Number of Residues	2
Details	binding site for residue CL C 407

Chain	Residue
C	ARG339
O	PHE362

site_id	AD3
Number of Residues	1
Details	binding site for residue CL C 408

Chain	Residue
C	SER184

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 C 409

Chain	Residue
B	ARG110
B	LYS114
C	SER184
C	TYR314
C	HOH503

site_id	AD5
Number of Residues	4
Details	binding site for residue NA C 411

Chain	Residue
C	ASP297
C	ASN300
O	ASP297
O	ASN300

site_id	AD6
Number of Residues	2
Details	binding site for residue NA D 201

Chain	Residue
D	GLU27
J	GLU34

site_id	AD7
Number of Residues	4
Details	binding site for residue NA D 202

Chain	Residue
D	PRO22
D	LYS23
D	GLU27
D	HOH309

site_id	AD8
Number of Residues	3
Details	binding site for residue CL D 203

Chain	Residue
D	ASN3
D	GLN13
D	HOH316

site_id	AD9
Number of Residues	1
Details	binding site for residue CL D 204

Chain	Residue
D	LYS23

site_id	AE1
Number of Residues	1
Details	binding site for residue CL D 205

Chain	Residue
D	LYS23

site_id	AE2
Number of Residues	1
Details	binding site for residue CL D 206

Chain	Residue
D	GLN122

site_id	AE3
Number of Residues	2
Details	binding site for residue CL D 207

Chain	Residue
D	ASP51
D	ARG114

site_id	AE4
Number of Residues	3
Details	binding site for residue SO4 D 208

Chain	Residue
D	ASN20
D	GLU21
D	HOH304

site_id	AE5
Number of Residues	5
Details	binding site for residue NA D 209

Chain	Residue
D	SER43
D	GLY71
E	TRP78
E	SER79
E	ASP80

site_id	AE6
Number of Residues	3
Details	binding site for residue NA E 201

Chain	Residue
E	LEU3
E	HIS4
E	HOH309

site_id	AE7
Number of Residues	1
Details	binding site for residue NA E 202

Chain	Residue
E	SO4207

site_id	AE8
Number of Residues	1
Details	binding site for residue CL E 204

Chain	Residue
E	ILE105

site_id	AE9
Number of Residues	3
Details	binding site for residue CL E 205

Chain	Residue
E	CYS1
E	TRP5
E	HOH308

site_id	AF1
Number of Residues	3
Details	binding site for residue CL E 206

Chain	Residue
D	TYR118
E	ASN69
E	ARG91

site_id	AF2
Number of Residues	3
Details	binding site for residue SO4 E 207

Chain	Residue
E	ASN68
E	LYS72
E	NA202

site_id	AF3
Number of Residues	6
Details	binding site for residue SO4 F 401

Chain	Residue
E	ARG110
E	LYS114
F	SER182
F	SER184
F	THR250
F	MG404

site_id	AF4
Number of Residues	1
Details	binding site for residue NA F 402

Chain	Residue
F	ASN318

site_id	AF5
Number of Residues	1
Details	binding site for residue NA F 403

Chain	Residue
F	ASP189

site_id	AF6
Number of Residues	4
Details	binding site for residue MG F 404

Chain	Residue
F	SER182
F	SER184
F	ASP283
F	SO4401

site_id	AF7
Number of Residues	1
Details	binding site for residue CL F 405

Chain	Residue
F	HOH510

site_id	AF8
Number of Residues	1
Details	binding site for residue SO4 F 406

Chain	Residue
F	ASN343

site_id	AF9
Number of Residues	2
Details	binding site for residue NA G 201

Chain	Residue
G	ASP47
G	HOH315

site_id	AG1
Number of Residues	1
Details	binding site for residue CL G 202

Chain	Residue
G	ASN125

site_id	AG2
Number of Residues	5
Details	binding site for residue GOL G 204

Chain	Residue
C	ARG221
C	VAL222
C	TYR258
G	GLN55
G	ASN59

site_id	AG3
Number of Residues	1
Details	binding site for residue GOL G 205

Chain	Residue
G	TYR67

site_id	AG4
Number of Residues	2
Details	binding site for residue NA H 201

Chain	Residue
H	TYR86
H	HOH307

site_id	AG5
Number of Residues	1
Details	binding site for residue CL H 202

Chain	Residue
H	LYS75

site_id	AG6
Number of Residues	1
Details	binding site for residue CL H 203

Chain	Residue
H	LYS59

site_id	AG7
Number of Residues	5
Details	binding site for residue GOL H 204

Chain	Residue
G	TRP25
H	GLU77
H	TRP78
H	SER79
H	ASP81

site_id	AG8
Number of Residues	3
Details	binding site for residue NA I 401

Chain	Residue
H	LEU90
I	ASN218
I	ASP248

site_id	AG9
Number of Residues	5
Details	binding site for residue NA I 402

Chain	Residue
I	GLY284
I	GLU285
I	SER286
I	GLU328
I	HOH503

site_id	AH1
Number of Residues	6
Details	binding site for residue MG I 403

Chain	Residue
I	ASP180
I	SER182
I	SER184
I	THR250
I	ASP283
I	SO4407

site_id	AH2
Number of Residues	2
Details	binding site for residue CL I 404

Chain	Residue
I	LEU305
I	ILE335

site_id	AH3
Number of Residues	1
Details	binding site for residue CL I 405

Chain	Residue
I	GLU347

site_id	AH4
Number of Residues	1
Details	binding site for residue CL I 406

Chain	Residue
I	GLN244

site_id	AH5
Number of Residues	5
Details	binding site for residue SO4 I 407

Chain	Residue
I	SER182
I	SER184
I	THR250
I	TYR314
I	MG403

site_id	AH6
Number of Residues	2
Details	binding site for residue NA J 201

Chain	Residue
J	ASP12
J	HIS14

site_id	AH7
Number of Residues	1
Details	binding site for residue NA J 202

Chain	Residue
J	ASP47

site_id	AH8
Number of Residues	1
Details	binding site for residue CL J 203

Chain	Residue
J	ARG114

site_id	AH9
Number of Residues	9
Details	binding site for residue GOL J 204

Chain	Residue
J	ILE44
J	ALA50
J	VAL53
J	ALA54
J	LEU107
J	PHE113
J	ARG114
J	TRP116
K	TYR86

site_id	AI1
Number of Residues	3
Details	binding site for residue GOL J 205

Chain	Residue
J	THR33
J	GLU34
J	ALA36

site_id	AI2
Number of Residues	1
Details	binding site for residue NA L 401

Chain	Residue
L	HIS287

site_id	AI3
Number of Residues	3
Details	binding site for residue NA L 402

Chain	Residue
L	SER286
L	GLU328
L	HOH510

site_id	AI4
Number of Residues	4
Details	binding site for residue MG L 403

Chain	Residue
L	SER184
L	ASP283
L	GLY284
L	SO4406

site_id	AI5
Number of Residues	1
Details	binding site for residue CL L 405

Chain	Residue
L	ASN318

site_id	AI6
Number of Residues	6
Details	binding site for residue SO4 L 406

Chain	Residue
K	ARG92
L	SER182
L	ASP248
L	THR250
L	MG403
L	HOH502

site_id	AI7
Number of Residues	1
Details	binding site for residue NA M 201

Chain	Residue
M	GLU27

site_id	AI8
Number of Residues	2
Details	binding site for residue CL M 202

Chain	Residue
M	GLN17
M	ALA18

site_id	AI9
Number of Residues	1
Details	binding site for residue CL M 203

Chain	Residue
M	PHE2

site_id	AJ1
Number of Residues	2
Details	binding site for residue NA N 201

Chain	Residue
N	SER43
N	GLU45

site_id	AJ2
Number of Residues	1
Details	binding site for residue CL N 202

Chain	Residue
N	ARG44

site_id	AJ3
Number of Residues	6
Details	binding site for residue CL N 203

Chain	Residue
N	ARG92
N	GLU113
N	LYS114
O	LEU249
O	HIS287
O	NA401

site_id	AJ4
Number of Residues	4
Details	binding site for residue NA O 401

Chain	Residue
N	ARG92
N	CL203
O	ASP248
O	SO4402

site_id	AJ5
Number of Residues	5
Details	binding site for residue SO4 O 402

Chain	Residue
N	ARG110
N	LYS114
O	TYR314
O	NA401
O	MG405

site_id	AJ6
Number of Residues	4
Details	binding site for residue NA O 403

Chain	Residue
N	LEU90
O	ASP248
O	HOH518
O	HOH520

site_id	AJ7
Number of Residues	4
Details	binding site for residue NA O 404

Chain	Residue
O	PRO187
O	TRP188
O	ASP189
O	HOH519

site_id	AJ8
Number of Residues	4
Details	binding site for residue MG O 405

Chain	Residue
O	ASP180
O	SER182
O	SER184
O	SO4402

site_id	AJ9
Number of Residues	3
Details	binding site for residue CL O 406

Chain	Residue
O	ARG221
O	VAL222
R	ASN227

site_id	AK1
Number of Residues	2
Details	binding site for residue SO4 O 407

Chain	Residue
O	ARG260
O	LYS261

site_id	AK2
Number of Residues	2
Details	binding site for residue NA P 201

Chain	Residue
P	PRO22
P	GLU65

site_id	AK3
Number of Residues	1
Details	binding site for residue CL P 202

Chain	Residue
P	ASN59

site_id	AK4
Number of Residues	2
Details	binding site for residue CL P 203

Chain	Residue
P	ASN95
P	TRP96

site_id	AK5
Number of Residues	3
Details	binding site for residue GOL P 204

Chain	Residue
P	GLU100
P	GLN102
P	HOH305

site_id	AK6
Number of Residues	2
Details	binding site for residue NA Q 201

Chain	Residue
Q	TYR60
R	THR322

site_id	AK7
Number of Residues	1
Details	binding site for residue NA Q 202

Chain	Residue
Q	GLU46

site_id	AK8
Number of Residues	1
Details	binding site for residue CL Q 203

Chain	Residue
Q	ARG44

site_id	AK9
Number of Residues	1
Details	binding site for residue CL Q 204

Chain	Residue
Q	LYS75

site_id	AL1
Number of Residues	1
Details	binding site for residue NA R 401

Chain	Residue
R	GLU196

site_id	AL2
Number of Residues	7
Details	binding site for residue MG R 402

Chain	Residue
R	ASP180
R	SER182
R	SER184
R	THR250
R	ASP283
R	GLY284
R	SO4404

site_id	AL3
Number of Residues	2
Details	binding site for residue CL R 403

Chain	Residue
R	LYS192
R	THR242

site_id	AL4
Number of Residues	7
Details	binding site for residue SO4 R 404

Chain	Residue
R	SER182
R	SER184
R	LEU249
R	THR250
R	MG402
R	HOH506
R	HOH507

Functional Information from PROSITE/UniProt

site_id	PS00615
Number of Residues	26
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CAvmvvktdrif..WFNRGCektvs.FVC

Chain	Residue	Details
B	CYS95-CYS120

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	928
Details	Domain: {"description":"C-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)