5TEM

Structure of 4-Hydroxy-tetrahydrodipicolinate Reductase from Vibrio vulnificus with 2,6 Pyridine Dicarboxylic and NADH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0016491	molecular_function	oxidoreductase activity
A	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
C	0009085	biological_process	lysine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0016491	molecular_function	oxidoreductase activity
C	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
C	0019877	biological_process	diaminopimelate biosynthetic process
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue NAD C 1001

Chain	Residue
C	GLY8
C	SER80
C	GLY98
C	THR100
C	ALA122
C	PRO123
C	ASN124
C	TYR125
C	LYS159
C	PDC1002
C	HOH1112
C	GLY11
C	HOH1126
C	HOH1128
C	HOH1145
C	HOH1157
C	HOH1160
C	HOH1181
C	ARG12
C	MET13
C	SER33
C	GLU34
C	ARG35
C	PHE75
C	THR76

---

site_id	AC2
Number of Residues	12
Details	binding site for residue PDC C 1002

Chain	Residue
C	THR100
C	PRO123
C	HIS156
C	LYS159
C	SER164
C	GLY165
C	THR166
C	NAD1001
C	HOH1112
C	HOH1129
C	HOH1145
C	HOH1156

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 C 1003

Chain	Residue
A	GLN89
C	LYS19
C	HIS23
C	MET237

---

site_id	AC4
Number of Residues	25
Details	binding site for residue NAD A 1001

Chain	Residue
A	GLY8
A	GLY11
A	ARG12
A	MET13
A	SER33
A	GLU34
A	ARG35
A	PHE75
A	THR76
A	SER80
A	GLY98
A	THR100
A	ALA122
A	PRO123
A	ASN124
A	TYR125
A	LYS159
A	PHE239
A	PDC1002
A	HOH1116
A	HOH1122
A	HOH1130
A	HOH1148
A	HOH1154
A	HOH1165

---

site_id	AC5
Number of Residues	11
Details	binding site for residue PDC A 1002

Chain	Residue
A	THR100
A	PRO123
A	HIS156
A	LYS159
A	SER164
A	GLY165
A	THR166
A	NAD1001
A	HOH1123
A	HOH1130
A	HOH1165

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 1003

Chain	Residue
A	GLU37
A	SER38
A	SER39
A	HOH1182

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 1004

Chain	Residue
A	ARG157
A	HIS158
A	ILE223

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 A 1005

Chain	Residue
A	THR103
A	GLU104
A	HOH1187

---

Functional Information from PROSITE/UniProt

site_id	PS01298
Number of Residues	18
Details	DAPB Dihydrodipicolinate reductase signature. EIvEaHhrhKvDapSGTA

Chain	Residue	Details
C	GLU150-ALA167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00102

Chain	Residue	Details
C	HIS155
A	HIS155

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00102

Chain	Residue	Details
C	LYS159
A	LYS159

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00102

Chain	Residue	Details
C	ARG35
C	GLY98
C	ALA122
C	HIS156
C	GLY165
A	GLY8
A	GLU34
A	ARG35
A	GLY98
A	ALA122
A	HIS156
A	GLY165
C	GLY8
C	GLU34

---