5TDN
Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | THR164 |
| A | ASP167 |
| A | HOH431 |
| B | HIS171 |
| B | HOH498 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 301 |
| Chain | Residue |
| B | SER135 |
| B | HOH401 |
| B | HOH402 |
| A | PRO119 |
| A | PHE209 |
| A | CYS214 |
| B | SER134 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 301 |
| Chain | Residue |
| C | THR164 |
| C | GLU165 |
| C | GLN166 |
| C | ASP167 |
| C | HOH408 |
| C | HOH483 |
| D | VAL170 |
| D | HIS171 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| A | TYR192-HIS198 | |
| B | TYR201-HIS207 |
