5TCZ
NMR solution structure of engineered Protoxin-II analog
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005246 | molecular_function | calcium channel regulator activity |
A | 0005576 | cellular_component | extracellular region |
A | 0008289 | molecular_function | lipid binding |
A | 0017080 | molecular_function | sodium channel regulator activity |
A | 0035821 | biological_process | modulation of process of another organism |
A | 0090729 | molecular_function | toxin activity |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Part of an aromatic-rich surface that anchors the toxin toward the membrane core relative to lipid headgroups bound along the pore module of Nav1.7/SCN9A => ECO:0000305|PubMed:30661758 |
Chain | Residue | Details |
A | TRP7 | |
A | GLN9 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Electrostatic gating-modifier of Nav1.7/SCN9A that antagonizes outward gating-charge movement through direct electrostatic repulsion; may also indirectly antagonize S4 gating-charge movement by neutralizing acidic side chains within the extracellular vestibule of VSD2 => ECO:0000305|PubMed:30661758 |
Chain | Residue | Details |
A | ARG24 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | SITE: Part of an aromatic-rich surface that anchors the toxin toward the membrane core relative to lipid headgroups bound along the pore module of Nav1.7/SCN9A; it also stabilizes the toxin for productive receptor site engagement => ECO:0000305|PubMed:30661758 |
Chain | Residue | Details |
A | TRP26 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Antagonizes outward gating-charge movement of Nav1.7/SCN9A through direct electrostatic repulsion; may also indirectly antagonize S4 gating-charge movement by neutralizing acidic side chains within the extracellular vestibule of VSD2 => ECO:0000305|PubMed:30661758 |
Chain | Residue | Details |
A | LYS28 |