5TCC

Complement Factor D inhibited with JH4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006956	biological_process	complement activation
A	0006957	biological_process	complement activation, alternative pathway
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009617	biological_process	response to bacterium
A	0016787	molecular_function	hydrolase activity
A	0031093	cellular_component	platelet alpha granule lumen
A	0031638	biological_process	zymogen activation
A	0034774	cellular_component	secretory granule lumen
A	0045087	biological_process	innate immune response
A	0051604	biological_process	protein maturation
A	0070062	cellular_component	extracellular exosome
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0002376	biological_process	immune system process
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006956	biological_process	complement activation
B	0006957	biological_process	complement activation, alternative pathway
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009617	biological_process	response to bacterium
B	0016787	molecular_function	hydrolase activity
B	0031093	cellular_component	platelet alpha granule lumen
B	0031638	biological_process	zymogen activation
B	0034774	cellular_component	secretory granule lumen
B	0045087	biological_process	innate immune response
B	0051604	biological_process	protein maturation
B	0070062	cellular_component	extracellular exosome
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0002376	biological_process	immune system process
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006508	biological_process	proteolysis
C	0006956	biological_process	complement activation
C	0006957	biological_process	complement activation, alternative pathway
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009617	biological_process	response to bacterium
C	0016787	molecular_function	hydrolase activity
C	0031093	cellular_component	platelet alpha granule lumen
C	0031638	biological_process	zymogen activation
C	0034774	cellular_component	secretory granule lumen
C	0045087	biological_process	innate immune response
C	0051604	biological_process	protein maturation
C	0070062	cellular_component	extracellular exosome
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0002376	biological_process	immune system process
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006508	biological_process	proteolysis
D	0006956	biological_process	complement activation
D	0006957	biological_process	complement activation, alternative pathway
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0009617	biological_process	response to bacterium
D	0016787	molecular_function	hydrolase activity
D	0031093	cellular_component	platelet alpha granule lumen
D	0031638	biological_process	zymogen activation
D	0034774	cellular_component	secretory granule lumen
D	0045087	biological_process	innate immune response
D	0051604	biological_process	protein maturation
D	0070062	cellular_component	extracellular exosome
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0002376	biological_process	immune system process
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006508	biological_process	proteolysis
E	0006956	biological_process	complement activation
E	0006957	biological_process	complement activation, alternative pathway
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0009617	biological_process	response to bacterium
E	0016787	molecular_function	hydrolase activity
E	0031093	cellular_component	platelet alpha granule lumen
E	0031638	biological_process	zymogen activation
E	0034774	cellular_component	secretory granule lumen
E	0045087	biological_process	innate immune response
E	0051604	biological_process	protein maturation
E	0070062	cellular_component	extracellular exosome
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0002376	biological_process	immune system process
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006508	biological_process	proteolysis
F	0006956	biological_process	complement activation
F	0006957	biological_process	complement activation, alternative pathway
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0009617	biological_process	response to bacterium
F	0016787	molecular_function	hydrolase activity
F	0031093	cellular_component	platelet alpha granule lumen
F	0031638	biological_process	zymogen activation
F	0034774	cellular_component	secretory granule lumen
F	0045087	biological_process	innate immune response
F	0051604	biological_process	protein maturation
F	0070062	cellular_component	extracellular exosome
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0002376	biological_process	immune system process
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006508	biological_process	proteolysis
G	0006956	biological_process	complement activation
G	0006957	biological_process	complement activation, alternative pathway
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0009617	biological_process	response to bacterium
G	0016787	molecular_function	hydrolase activity
G	0031093	cellular_component	platelet alpha granule lumen
G	0031638	biological_process	zymogen activation
G	0034774	cellular_component	secretory granule lumen
G	0045087	biological_process	innate immune response
G	0051604	biological_process	protein maturation
G	0070062	cellular_component	extracellular exosome
G	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue J56 A 500

Chain	Residue
A	LEU40
A	SER214
A	GLY215
A	SER216
A	ARG217
A	CYS219
C	HIS148
C	ALA149
A	HIS56
A	CYS57
A	TRP143
A	ARG152
A	LYS195
A	GLY196
A	SER198
A	THR213

---

site_id	AC2
Number of Residues	12
Details	binding site for residue J56 B 500

Chain	Residue
B	LEU40
B	CYS41
B	TRP143
B	LYS195
B	GLY196
B	SER198
B	THR213
B	SER214
B	GLY215
B	SER216
B	ARG217
B	CYS219

---

site_id	AC3
Number of Residues	14
Details	binding site for residue J56 C 301

Chain	Residue
A	ALA149
C	LEU40
C	HIS56
C	CYS57
C	TRP143
C	LYS195
C	GLY196
C	SER198
C	THR213
C	SER214
C	GLY215
C	SER216
C	ARG217
C	CYS219

---

site_id	AC4
Number of Residues	8
Details	binding site for residue J56 C 302

Chain	Residue
A	VAL87
A	ALA90
C	GLY135
C	LEU137
C	HIS158
C	LEU160
C	PRO162
C	ARG191

---

site_id	AC5
Number of Residues	16
Details	binding site for residue J56 D 500

Chain	Residue
D	LEU40
D	CYS41
D	HIS56
D	CYS57
D	GLU59
D	TRP143
D	ARG152
D	LYS195
D	GLY196
D	SER198
D	THR213
D	SER214
D	GLY215
D	SER216
D	ARG217
D	CYS219

---

site_id	AC6
Number of Residues	14
Details	binding site for residue J56 E 301

Chain	Residue
E	LEU40
E	HIS56
E	CYS57
E	TRP143
E	LYS195
E	GLY196
E	SER198
E	THR213
E	SER214
E	GLY215
E	SER216
E	ARG217
E	CYS219
F	ALA149

---

site_id	AC7
Number of Residues	5
Details	binding site for residue J56 E 302

Chain	Residue
D	ALA90
E	GLY18
E	LEU137
E	LEU160
E	GLU187

---

site_id	AC8
Number of Residues	14
Details	binding site for residue J56 F 500

Chain	Residue
E	ALA149
F	LEU40
F	HIS56
F	CYS57
F	TRP143
F	ARG152
F	LYS195
F	GLY196
F	SER198
F	THR213
F	SER214
F	GLY215
F	SER216
F	ARG217

---

site_id	AC9
Number of Residues	14
Details	binding site for residue J56 G 500

Chain	Residue
G	LEU40
G	HIS56
G	CYS57
G	TRP143
G	ARG152
G	LYS195
G	GLY196
G	SER198
G	THR213
G	SER214
G	GLY215
G	SER216
G	ARG217
G	CYS219

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC

Chain	Residue	Details
A	LEU52-CYS57

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV

Chain	Residue	Details
A	ASP192-VAL203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1362
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Region: {"description":"Self-inhibitor loop","evidences":[{"source":"PubMed","id":"10022823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9753554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9753554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21205667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22362762","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---