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5TB0

Structure of rabbit RyR1 (EGTA-only dataset, all particles)

This is a non-PDB format compatible entry.
Replaces:  3J8E
Functional Information from GO Data
ChainGOidnamespacecontents
A0002027biological_processregulation of heart rate
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005102molecular_functionsignaling receptor binding
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005515molecular_functionprotein binding
A0005528molecular_functionFK506 binding
A0005737cellular_componentcytoplasm
A0006458biological_process'de novo' protein folding
A0006939biological_processsmooth muscle contraction
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0009749biological_processresponse to glucose
A0010459biological_processnegative regulation of heart rate
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016247molecular_functionchannel regulator activity
A0016529cellular_componentsarcoplasmic reticulum
A0019227biological_processneuronal action potential propagation
A0019722biological_processcalcium-mediated signaling
A0019855molecular_functioncalcium channel inhibitor activity
A0022417biological_processprotein maturation by protein folding
A0030018cellular_componentZ disc
A0030073biological_processinsulin secretion
A0030551molecular_functioncyclic nucleotide binding
A0033017cellular_componentsarcoplasmic reticulum membrane
A0033197biological_processresponse to vitamin E
A0034704cellular_componentcalcium channel complex
A0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
A0042026biological_processprotein refolding
A0042098biological_processT cell proliferation
A0042542biological_processresponse to hydrogen peroxide
A0044325molecular_functiontransmembrane transporter binding
A0048680biological_processpositive regulation of axon regeneration
A0050849biological_processnegative regulation of calcium-mediated signaling
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
A0051284biological_processpositive regulation of sequestering of calcium ion
A0051775biological_processresponse to redox state
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005262molecular_functioncalcium channel activity
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0016020cellular_componentmembrane
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
E0005216molecular_functionmonoatomic ion channel activity
E0005219molecular_functionryanodine-sensitive calcium-release channel activity
E0005262molecular_functioncalcium channel activity
E0006811biological_processmonoatomic ion transport
E0006816biological_processcalcium ion transport
E0006874biological_processintracellular calcium ion homeostasis
E0016020cellular_componentmembrane
E0055085biological_processtransmembrane transport
E0070588biological_processcalcium ion transmembrane transport
F0002027biological_processregulation of heart rate
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005102molecular_functionsignaling receptor binding
F0005219molecular_functionryanodine-sensitive calcium-release channel activity
F0005515molecular_functionprotein binding
F0005528molecular_functionFK506 binding
F0005737cellular_componentcytoplasm
F0006458biological_process'de novo' protein folding
F0006939biological_processsmooth muscle contraction
F0007204biological_processpositive regulation of cytosolic calcium ion concentration
F0009749biological_processresponse to glucose
F0010459biological_processnegative regulation of heart rate
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016247molecular_functionchannel regulator activity
F0016529cellular_componentsarcoplasmic reticulum
F0019227biological_processneuronal action potential propagation
F0019722biological_processcalcium-mediated signaling
F0019855molecular_functioncalcium channel inhibitor activity
F0022417biological_processprotein maturation by protein folding
F0030018cellular_componentZ disc
F0030073biological_processinsulin secretion
F0030551molecular_functioncyclic nucleotide binding
F0033017cellular_componentsarcoplasmic reticulum membrane
F0033197biological_processresponse to vitamin E
F0034704cellular_componentcalcium channel complex
F0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
F0042026biological_processprotein refolding
F0042098biological_processT cell proliferation
F0042542biological_processresponse to hydrogen peroxide
F0044325molecular_functiontransmembrane transporter binding
F0048680biological_processpositive regulation of axon regeneration
F0050849biological_processnegative regulation of calcium-mediated signaling
F0051209biological_processrelease of sequestered calcium ion into cytosol
F0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
F0051284biological_processpositive regulation of sequestering of calcium ion
F0051775biological_processresponse to redox state
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
G0005216molecular_functionmonoatomic ion channel activity
G0005219molecular_functionryanodine-sensitive calcium-release channel activity
G0005262molecular_functioncalcium channel activity
G0006811biological_processmonoatomic ion transport
G0006816biological_processcalcium ion transport
G0006874biological_processintracellular calcium ion homeostasis
G0016020cellular_componentmembrane
G0055085biological_processtransmembrane transport
G0070588biological_processcalcium ion transmembrane transport
H0002027biological_processregulation of heart rate
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005102molecular_functionsignaling receptor binding
H0005219molecular_functionryanodine-sensitive calcium-release channel activity
H0005515molecular_functionprotein binding
H0005528molecular_functionFK506 binding
H0005737cellular_componentcytoplasm
H0006458biological_process'de novo' protein folding
H0006939biological_processsmooth muscle contraction
H0007204biological_processpositive regulation of cytosolic calcium ion concentration
H0009749biological_processresponse to glucose
H0010459biological_processnegative regulation of heart rate
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016247molecular_functionchannel regulator activity
H0016529cellular_componentsarcoplasmic reticulum
H0019227biological_processneuronal action potential propagation
H0019722biological_processcalcium-mediated signaling
H0019855molecular_functioncalcium channel inhibitor activity
H0022417biological_processprotein maturation by protein folding
H0030018cellular_componentZ disc
H0030073biological_processinsulin secretion
H0030551molecular_functioncyclic nucleotide binding
H0033017cellular_componentsarcoplasmic reticulum membrane
H0033197biological_processresponse to vitamin E
H0034704cellular_componentcalcium channel complex
H0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
H0042026biological_processprotein refolding
H0042098biological_processT cell proliferation
H0042542biological_processresponse to hydrogen peroxide
H0044325molecular_functiontransmembrane transporter binding
H0048680biological_processpositive regulation of axon regeneration
H0050849biological_processnegative regulation of calcium-mediated signaling
H0051209biological_processrelease of sequestered calcium ion into cytosol
H0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
H0051284biological_processpositive regulation of sequestering of calcium ion
H0051775biological_processresponse to redox state
H0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
H0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
I0005216molecular_functionmonoatomic ion channel activity
I0005219molecular_functionryanodine-sensitive calcium-release channel activity
I0005262molecular_functioncalcium channel activity
I0006811biological_processmonoatomic ion transport
I0006816biological_processcalcium ion transport
I0006874biological_processintracellular calcium ion homeostasis
I0016020cellular_componentmembrane
I0055085biological_processtransmembrane transport
I0070588biological_processcalcium ion transmembrane transport
J0002027biological_processregulation of heart rate
J0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
J0005102molecular_functionsignaling receptor binding
J0005219molecular_functionryanodine-sensitive calcium-release channel activity
J0005515molecular_functionprotein binding
J0005528molecular_functionFK506 binding
J0005737cellular_componentcytoplasm
J0006458biological_process'de novo' protein folding
J0006939biological_processsmooth muscle contraction
J0007204biological_processpositive regulation of cytosolic calcium ion concentration
J0009749biological_processresponse to glucose
J0010459biological_processnegative regulation of heart rate
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J0016020cellular_componentmembrane
J0016247molecular_functionchannel regulator activity
J0016529cellular_componentsarcoplasmic reticulum
J0019227biological_processneuronal action potential propagation
J0019722biological_processcalcium-mediated signaling
J0019855molecular_functioncalcium channel inhibitor activity
J0022417biological_processprotein maturation by protein folding
J0030018cellular_componentZ disc
J0030073biological_processinsulin secretion
J0030551molecular_functioncyclic nucleotide binding
J0033017cellular_componentsarcoplasmic reticulum membrane
J0033197biological_processresponse to vitamin E
J0034704cellular_componentcalcium channel complex
J0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
J0042026biological_processprotein refolding
J0042098biological_processT cell proliferation
J0042542biological_processresponse to hydrogen peroxide
J0044325molecular_functiontransmembrane transporter binding
J0048680biological_processpositive regulation of axon regeneration
J0050849biological_processnegative regulation of calcium-mediated signaling
J0051209biological_processrelease of sequestered calcium ion into cytosol
J0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
J0051284biological_processpositive regulation of sequestering of calcium ion
J0051775biological_processresponse to redox state
J0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue ZN B 6000
ChainResidue
BCYS4958
BILE4960
BCYS4961
BHIS4978
BHIS4983

site_idAC2
Number of Residues5
Detailsbinding site for residue ZN G 6000
ChainResidue
GHIS4983
GCYS4958
GILE4960
GCYS4961
GHIS4978

site_idAC3
Number of Residues5
Detailsbinding site for residue ZN E 6000
ChainResidue
ECYS4958
EILE4960
ECYS4961
EHIS4978
EHIS4983

site_idAC4
Number of Residues5
Detailsbinding site for residue ZN I 6000
ChainResidue
ICYS4958
IILE4960
ICYS4961
IHIS4978
IHIS4983

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
BPHE4559-PHE4579
GPHE4559-PHE4579
EPHE4559-PHE4579
IPHE4559-PHE4579

site_idSWS_FT_FI2
Number of Residues408
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
BTYR4580-GLU4640
EHIS4803
EASN4857-MET4879
EGLU4900-THR4919
ITYR4580-GLU4640
IHIS4803
IASN4857-MET4879
IGLU4900-THR4919
BHIS4803
BASN4857-MET4879
BGLU4900-THR4919
GTYR4580-GLU4640
GHIS4803
GASN4857-MET4879
GGLU4900-THR4919
ETYR4580-GLU4640

site_idSWS_FT_FI3
Number of Residues80
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
BPRO4641-TYR4661
GPRO4641-TYR4661
EPRO4641-TYR4661
IPRO4641-TYR4661

site_idSWS_FT_FI4
Number of Residues908
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
BASN4662-LYS4779
IASN4662-LYS4779
ILYS4821-LYS4835
IGLY4941-SER5037
BLYS4821-LYS4835
BGLY4941-SER5037
GASN4662-LYS4779
GLYS4821-LYS4835
GGLY4941-SER5037
EASN4662-LYS4779
ELYS4821-LYS4835
EGLY4941-SER5037

site_idSWS_FT_FI5
Number of Residues88
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
BPHE4780-GLY4802
GPHE4780-GLY4802
EPHE4780-GLY4802
IPHE4780-GLY4802

site_idSWS_FT_FI6
Number of Residues64
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
BTYR4804-VAL4820
GTYR4804-VAL4820
ETYR4804-VAL4820
ITYR4804-VAL4820

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
BGLN4836-PHE4856
GGLN4836-PHE4856
EGLN4836-PHE4856
IGLN4836-PHE4856

site_idSWS_FT_FI8
Number of Residues76
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
BMET4880-ASP4899
GMET4880-ASP4899
EMET4880-ASP4899
IMET4880-ASP4899

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
BPHE4920-PHE4940
GPHE4920-PHE4940
EPHE4920-PHE4940
IPHE4920-PHE4940

site_idSWS_FT_FI10
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN
ChainResidueDetails
BGLU3893
IGLU3893
IGLU3967
ITHR5001
BGLU3967
BTHR5001
GGLU3893
GGLU3967
GTHR5001
EGLU3893
EGLU3967
ETHR5001

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5T9V, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN, ECO:0007744|PDB:5TAS, ECO:0007744|PDB:5TAT, ECO:0007744|PDB:5TAU
ChainResidueDetails
BLYS4211
ILYS4211
IMET4954
ITHR4979
BMET4954
BTHR4979
GLYS4211
GMET4954
GTHR4979
ELYS4211
EMET4954
ETHR4979

site_idSWS_FT_FI12
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TAN
ChainResidueDetails
BTRP4716
GTRP4716
ETRP4716
ITRP4716

site_idSWS_FT_FI13
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
BUNK1470
IUNK1470
ISER2345
BSER2345
GUNK1470
GSER2345
EUNK1470
ESER2345

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA and PKG => ECO:0000269|PubMed:8380342
ChainResidueDetails
BSER2843
GSER2843
ESER2843
ISER2843

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:10601232, ECO:0000269|PubMed:11562475, ECO:0000269|PubMed:22036948
ChainResidueDetails
BLEU3985
GLEU3985
ELEU3985
ILEU3985

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
BTYR4863
GTYR4863
ETYR4863
ITYR4863

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
BSER4866
GSER4866
ESER4866
ISER4866

226707

PDB entries from 2024-10-30

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