5TAT

Structure of rabbit RyR1 (Caffeine/ATP/EGTA dataset, class 2)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002027	biological_process	regulation of heart rate
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005102	molecular_function	signaling receptor binding
A	0005246	molecular_function	calcium channel regulator activity
A	0005515	molecular_function	protein binding
A	0005528	molecular_function	FK506 binding
A	0005737	cellular_component	cytoplasm
A	0006458	biological_process	'de novo' protein folding
A	0006939	biological_process	smooth muscle contraction
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0009749	biological_process	response to glucose
A	0010459	biological_process	negative regulation of heart rate
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0016853	molecular_function	isomerase activity
A	0019227	biological_process	neuronal action potential propagation
A	0019722	biological_process	calcium-mediated signaling
A	0019855	molecular_function	calcium channel inhibitor activity
A	0030018	cellular_component	Z disc
A	0030073	biological_process	insulin secretion
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0034704	cellular_component	calcium channel complex
A	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
A	0042026	biological_process	protein refolding
A	0042098	biological_process	T cell proliferation
A	0044325	molecular_function	transmembrane transporter binding
A	0050849	biological_process	negative regulation of calcium-mediated signaling
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
A	0051284	biological_process	positive regulation of sequestering of calcium ion
A	0051604	biological_process	protein maturation
A	0051775	biological_process	response to redox state
A	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
B	0005216	molecular_function	monoatomic ion channel activity
B	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
B	0005262	molecular_function	calcium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
E	0005216	molecular_function	monoatomic ion channel activity
E	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
E	0005262	molecular_function	calcium channel activity
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport
E	0070588	biological_process	calcium ion transmembrane transport
F	0002027	biological_process	regulation of heart rate
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005102	molecular_function	signaling receptor binding
F	0005246	molecular_function	calcium channel regulator activity
F	0005515	molecular_function	protein binding
F	0005528	molecular_function	FK506 binding
F	0005737	cellular_component	cytoplasm
F	0006458	biological_process	'de novo' protein folding
F	0006939	biological_process	smooth muscle contraction
F	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
F	0009749	biological_process	response to glucose
F	0010459	biological_process	negative regulation of heart rate
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016529	cellular_component	sarcoplasmic reticulum
F	0016853	molecular_function	isomerase activity
F	0019227	biological_process	neuronal action potential propagation
F	0019722	biological_process	calcium-mediated signaling
F	0019855	molecular_function	calcium channel inhibitor activity
F	0030018	cellular_component	Z disc
F	0030073	biological_process	insulin secretion
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0034704	cellular_component	calcium channel complex
F	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
F	0042026	biological_process	protein refolding
F	0042098	biological_process	T cell proliferation
F	0044325	molecular_function	transmembrane transporter binding
F	0050849	biological_process	negative regulation of calcium-mediated signaling
F	0051209	biological_process	release of sequestered calcium ion into cytosol
F	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
F	0051284	biological_process	positive regulation of sequestering of calcium ion
F	0051604	biological_process	protein maturation
F	0051775	biological_process	response to redox state
F	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
G	0005216	molecular_function	monoatomic ion channel activity
G	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
G	0005262	molecular_function	calcium channel activity
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0006874	biological_process	intracellular calcium ion homeostasis
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport
G	0070588	biological_process	calcium ion transmembrane transport
H	0002027	biological_process	regulation of heart rate
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005102	molecular_function	signaling receptor binding
H	0005246	molecular_function	calcium channel regulator activity
H	0005515	molecular_function	protein binding
H	0005528	molecular_function	FK506 binding
H	0005737	cellular_component	cytoplasm
H	0006458	biological_process	'de novo' protein folding
H	0006939	biological_process	smooth muscle contraction
H	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
H	0009749	biological_process	response to glucose
H	0010459	biological_process	negative regulation of heart rate
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016529	cellular_component	sarcoplasmic reticulum
H	0016853	molecular_function	isomerase activity
H	0019227	biological_process	neuronal action potential propagation
H	0019722	biological_process	calcium-mediated signaling
H	0019855	molecular_function	calcium channel inhibitor activity
H	0030018	cellular_component	Z disc
H	0030073	biological_process	insulin secretion
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0034704	cellular_component	calcium channel complex
H	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
H	0042026	biological_process	protein refolding
H	0042098	biological_process	T cell proliferation
H	0044325	molecular_function	transmembrane transporter binding
H	0050849	biological_process	negative regulation of calcium-mediated signaling
H	0051209	biological_process	release of sequestered calcium ion into cytosol
H	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
H	0051284	biological_process	positive regulation of sequestering of calcium ion
H	0051604	biological_process	protein maturation
H	0051775	biological_process	response to redox state
H	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
I	0005216	molecular_function	monoatomic ion channel activity
I	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
I	0005262	molecular_function	calcium channel activity
I	0006811	biological_process	monoatomic ion transport
I	0006816	biological_process	calcium ion transport
I	0006874	biological_process	intracellular calcium ion homeostasis
I	0016020	cellular_component	membrane
I	0055085	biological_process	transmembrane transport
I	0070588	biological_process	calcium ion transmembrane transport
J	0002027	biological_process	regulation of heart rate
J	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
J	0005102	molecular_function	signaling receptor binding
J	0005246	molecular_function	calcium channel regulator activity
J	0005515	molecular_function	protein binding
J	0005528	molecular_function	FK506 binding
J	0005737	cellular_component	cytoplasm
J	0006458	biological_process	'de novo' protein folding
J	0006939	biological_process	smooth muscle contraction
J	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
J	0009749	biological_process	response to glucose
J	0010459	biological_process	negative regulation of heart rate
J	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J	0016020	cellular_component	membrane
J	0016529	cellular_component	sarcoplasmic reticulum
J	0016853	molecular_function	isomerase activity
J	0019227	biological_process	neuronal action potential propagation
J	0019722	biological_process	calcium-mediated signaling
J	0019855	molecular_function	calcium channel inhibitor activity
J	0030018	cellular_component	Z disc
J	0030073	biological_process	insulin secretion
J	0033017	cellular_component	sarcoplasmic reticulum membrane
J	0034704	cellular_component	calcium channel complex
J	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
J	0042026	biological_process	protein refolding
J	0042098	biological_process	T cell proliferation
J	0044325	molecular_function	transmembrane transporter binding
J	0050849	biological_process	negative regulation of calcium-mediated signaling
J	0051209	biological_process	release of sequestered calcium ion into cytosol
J	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
J	0051284	biological_process	positive regulation of sequestering of calcium ion
J	0051604	biological_process	protein maturation
J	0051775	biological_process	response to redox state
J	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue ATP B 5101

Chain	Residue
B	LYS4211
B	ARG4215
B	MET4954
B	CYS4958
B	ILE4960
B	THR4979
B	HIS4983
B	LEU4985

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CFF B 5102

Chain	Residue
B	TRP4716
B	ILE4996
B	TRP5011
B	TYR5014
B	GLU4239

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 5103

Chain	Residue
B	CYS4958
B	CYS4961
B	HIS4978
B	HIS4983

---

site_id	AC4
Number of Residues	8
Details	binding site for residue ATP I 5101

Chain	Residue
I	LYS4211
I	ARG4215
I	MET4954
I	CYS4958
I	ILE4960
I	THR4979
I	HIS4983
I	LEU4985

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CFF I 5102

Chain	Residue
I	GLU4239
I	TRP4716
I	ILE4996
I	TRP5011
I	TYR5014

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN I 5103

Chain	Residue
I	CYS4958
I	CYS4961
I	HIS4978
I	HIS4983

---

site_id	AC7
Number of Residues	8
Details	binding site for residue ATP E 5101

Chain	Residue
E	LYS4211
E	ARG4215
E	MET4954
E	CYS4958
E	ILE4960
E	THR4979
E	HIS4983
E	LEU4985

---

site_id	AC8
Number of Residues	5
Details	binding site for residue CFF E 5102

Chain	Residue
E	GLU4239
E	TRP4716
E	ILE4996
E	TRP5011
E	TYR5014

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN E 5103

Chain	Residue
E	CYS4958
E	CYS4961
E	HIS4978
E	HIS4983

---

site_id	AD1
Number of Residues	8
Details	binding site for residue ATP G 5101

Chain	Residue
G	LYS4211
G	ARG4215
G	MET4954
G	CYS4958
G	ILE4960
G	THR4979
G	HIS4983
G	LEU4985

---

site_id	AD2
Number of Residues	5
Details	binding site for residue CFF G 5102

Chain	Residue
G	GLU4239
G	TRP4716
G	ILE4996
G	TRP5011
G	TYR5014

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN G 5103

Chain	Residue
G	CYS4958
G	CYS4961
G	HIS4978
G	HIS4983

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	352
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	220
Details	Domain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	180
Details	Domain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	216
Details	Domain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	252
Details	Domain: {"description":"MIR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	232
Details	Domain: {"description":"MIR 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	864
Details	Domain: {"description":"B30.2/SPRY 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00548","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	44
Details	Region: {"description":"Interaction with FKBP1A","evidences":[{"source":"PubMed","id":"26245150","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	428
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	208
Details	Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"F1LMY4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKA and PKG","evidences":[{"source":"PubMed","id":"8380342","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---