5TAN

Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 3)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002027	biological_process	regulation of heart rate
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005102	molecular_function	signaling receptor binding
A	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
A	0005515	molecular_function	protein binding
A	0005528	molecular_function	FK506 binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006458	biological_process	'de novo' protein folding
A	0006939	biological_process	smooth muscle contraction
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0009749	biological_process	response to glucose
A	0010033	biological_process	response to organic substance
A	0010459	biological_process	negative regulation of heart rate
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016247	molecular_function	channel regulator activity
A	0016529	cellular_component	sarcoplasmic reticulum
A	0019227	biological_process	neuronal action potential propagation
A	0019722	biological_process	calcium-mediated signaling
A	0019855	molecular_function	calcium channel inhibitor activity
A	0022417	biological_process	protein maturation by protein folding
A	0030018	cellular_component	Z disc
A	0030073	biological_process	insulin secretion
A	0030551	molecular_function	cyclic nucleotide binding
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0033197	biological_process	response to vitamin E
A	0034704	cellular_component	calcium channel complex
A	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
A	0042026	biological_process	protein refolding
A	0042098	biological_process	T cell proliferation
A	0042542	biological_process	response to hydrogen peroxide
A	0044325	molecular_function	transmembrane transporter binding
A	0048680	biological_process	positive regulation of axon regeneration
A	0050849	biological_process	negative regulation of calcium-mediated signaling
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
A	0051284	biological_process	positive regulation of sequestering of calcium ion
A	0051480	biological_process	regulation of cytosolic calcium ion concentration
A	0051775	biological_process	response to redox state
A	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
B	0005216	molecular_function	monoatomic ion channel activity
B	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
B	0005262	molecular_function	calcium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
E	0005216	molecular_function	monoatomic ion channel activity
E	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
E	0005262	molecular_function	calcium channel activity
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport
E	0070588	biological_process	calcium ion transmembrane transport
F	0002027	biological_process	regulation of heart rate
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005102	molecular_function	signaling receptor binding
F	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
F	0005515	molecular_function	protein binding
F	0005528	molecular_function	FK506 binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006458	biological_process	'de novo' protein folding
F	0006939	biological_process	smooth muscle contraction
F	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
F	0009749	biological_process	response to glucose
F	0010033	biological_process	response to organic substance
F	0010459	biological_process	negative regulation of heart rate
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016247	molecular_function	channel regulator activity
F	0016529	cellular_component	sarcoplasmic reticulum
F	0019227	biological_process	neuronal action potential propagation
F	0019722	biological_process	calcium-mediated signaling
F	0019855	molecular_function	calcium channel inhibitor activity
F	0022417	biological_process	protein maturation by protein folding
F	0030018	cellular_component	Z disc
F	0030073	biological_process	insulin secretion
F	0030551	molecular_function	cyclic nucleotide binding
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0033197	biological_process	response to vitamin E
F	0034704	cellular_component	calcium channel complex
F	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
F	0042026	biological_process	protein refolding
F	0042098	biological_process	T cell proliferation
F	0042542	biological_process	response to hydrogen peroxide
F	0044325	molecular_function	transmembrane transporter binding
F	0048680	biological_process	positive regulation of axon regeneration
F	0050849	biological_process	negative regulation of calcium-mediated signaling
F	0051209	biological_process	release of sequestered calcium ion into cytosol
F	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
F	0051284	biological_process	positive regulation of sequestering of calcium ion
F	0051480	biological_process	regulation of cytosolic calcium ion concentration
F	0051775	biological_process	response to redox state
F	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
G	0005216	molecular_function	monoatomic ion channel activity
G	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
G	0005262	molecular_function	calcium channel activity
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0006874	biological_process	intracellular calcium ion homeostasis
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport
G	0070588	biological_process	calcium ion transmembrane transport
H	0002027	biological_process	regulation of heart rate
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005102	molecular_function	signaling receptor binding
H	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
H	0005515	molecular_function	protein binding
H	0005528	molecular_function	FK506 binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006458	biological_process	'de novo' protein folding
H	0006939	biological_process	smooth muscle contraction
H	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
H	0009749	biological_process	response to glucose
H	0010033	biological_process	response to organic substance
H	0010459	biological_process	negative regulation of heart rate
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016247	molecular_function	channel regulator activity
H	0016529	cellular_component	sarcoplasmic reticulum
H	0019227	biological_process	neuronal action potential propagation
H	0019722	biological_process	calcium-mediated signaling
H	0019855	molecular_function	calcium channel inhibitor activity
H	0022417	biological_process	protein maturation by protein folding
H	0030018	cellular_component	Z disc
H	0030073	biological_process	insulin secretion
H	0030551	molecular_function	cyclic nucleotide binding
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0033197	biological_process	response to vitamin E
H	0034704	cellular_component	calcium channel complex
H	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
H	0042026	biological_process	protein refolding
H	0042098	biological_process	T cell proliferation
H	0042542	biological_process	response to hydrogen peroxide
H	0044325	molecular_function	transmembrane transporter binding
H	0048680	biological_process	positive regulation of axon regeneration
H	0050849	biological_process	negative regulation of calcium-mediated signaling
H	0051209	biological_process	release of sequestered calcium ion into cytosol
H	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
H	0051284	biological_process	positive regulation of sequestering of calcium ion
H	0051480	biological_process	regulation of cytosolic calcium ion concentration
H	0051775	biological_process	response to redox state
H	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
I	0005216	molecular_function	monoatomic ion channel activity
I	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
I	0005262	molecular_function	calcium channel activity
I	0006811	biological_process	monoatomic ion transport
I	0006816	biological_process	calcium ion transport
I	0006874	biological_process	intracellular calcium ion homeostasis
I	0016020	cellular_component	membrane
I	0055085	biological_process	transmembrane transport
I	0070588	biological_process	calcium ion transmembrane transport
J	0002027	biological_process	regulation of heart rate
J	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
J	0005102	molecular_function	signaling receptor binding
J	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
J	0005515	molecular_function	protein binding
J	0005528	molecular_function	FK506 binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006458	biological_process	'de novo' protein folding
J	0006939	biological_process	smooth muscle contraction
J	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
J	0009749	biological_process	response to glucose
J	0010033	biological_process	response to organic substance
J	0010459	biological_process	negative regulation of heart rate
J	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J	0016020	cellular_component	membrane
J	0016247	molecular_function	channel regulator activity
J	0016529	cellular_component	sarcoplasmic reticulum
J	0019227	biological_process	neuronal action potential propagation
J	0019722	biological_process	calcium-mediated signaling
J	0019855	molecular_function	calcium channel inhibitor activity
J	0022417	biological_process	protein maturation by protein folding
J	0030018	cellular_component	Z disc
J	0030073	biological_process	insulin secretion
J	0030551	molecular_function	cyclic nucleotide binding
J	0033017	cellular_component	sarcoplasmic reticulum membrane
J	0033197	biological_process	response to vitamin E
J	0034704	cellular_component	calcium channel complex
J	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
J	0042026	biological_process	protein refolding
J	0042098	biological_process	T cell proliferation
J	0042542	biological_process	response to hydrogen peroxide
J	0044325	molecular_function	transmembrane transporter binding
J	0048680	biological_process	positive regulation of axon regeneration
J	0050849	biological_process	negative regulation of calcium-mediated signaling
J	0051209	biological_process	release of sequestered calcium ion into cytosol
J	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
J	0051284	biological_process	positive regulation of sequestering of calcium ion
J	0051480	biological_process	regulation of cytosolic calcium ion concentration
J	0051775	biological_process	response to redox state
J	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue ATP B 5101

Chain	Residue
B	LYS4211
B	ARG4215
B	MET4954
B	CYS4958
B	PHE4975
B	ASN4984
B	LEU4985

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CFF B 5102

Chain	Residue
B	TRP5011
B	TYR5014
B	TRP4716
B	ILE4996

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 5103

Chain	Residue
B	CYS4958
B	CYS4961
B	HIS4978
B	HIS4983

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CA B 5104

Chain	Residue
B	GLU3893
B	GLU3967
B	THR5001
B	HIS5003

---

site_id	AC5
Number of Residues	7
Details	binding site for residue ATP E 5101

Chain	Residue
E	LYS4211
E	ARG4215
E	MET4954
E	CYS4958
E	PHE4975
E	ASN4984
E	LEU4985

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CFF E 5102

Chain	Residue
E	TRP4716
E	ILE4996
E	TRP5011
E	TYR5014

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN E 5103

Chain	Residue
E	CYS4958
E	CYS4961
E	HIS4978
E	HIS4983

---

site_id	AC8
Number of Residues	4
Details	binding site for residue CA E 5104

Chain	Residue
E	GLU3893
E	GLU3967
E	THR5001
E	HIS5003

---

site_id	AC9
Number of Residues	7
Details	binding site for residue ATP I 5101

Chain	Residue
I	LYS4211
I	ARG4215
I	MET4954
I	CYS4958
I	PHE4975
I	ASN4984
I	LEU4985

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CFF I 5102

Chain	Residue
I	TRP4716
I	ILE4996
I	TRP5011
I	TYR5014

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN I 5103

Chain	Residue
I	CYS4958
I	CYS4961
I	HIS4978
I	HIS4983

---

site_id	AD3
Number of Residues	4
Details	binding site for residue CA I 5104

Chain	Residue
I	GLU3893
I	GLU3967
I	THR5001
I	HIS5003

---

site_id	AD4
Number of Residues	7
Details	binding site for residue ATP G 5101

Chain	Residue
G	LYS4211
G	ARG4215
G	MET4954
G	CYS4958
G	PHE4975
G	ASN4984
G	LEU4985

---

site_id	AD5
Number of Residues	4
Details	binding site for residue CFF G 5102

Chain	Residue
G	TRP4716
G	ILE4996
G	TRP5011
G	TYR5014

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN G 5103

Chain	Residue
G	CYS4958
G	CYS4961
G	HIS4978
G	HIS4983

---

site_id	AD7
Number of Residues	4
Details	binding site for residue CA G 5104

Chain	Residue
G	GLU3893
G	GLU3967
G	THR5001
G	HIS5003

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175

Chain	Residue	Details
E	PHE4559-PHE4579
B	PHE4559-PHE4579
I	PHE4559-PHE4579
G	PHE4559-PHE4579

---

site_id	SWS_FT_FI2
Number of Residues	408
Details	TOPO_DOM: Lumenal => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175

Chain	Residue	Details
B	HIS4803
E	TYR4580-GLU4640
E	HIS4803
E	ASN4857-MET4879
E	GLU4900-THR4919
I	HIS4803
G	HIS4803
B	TYR4580-GLU4640
B	ASN4857-MET4879
B	GLU4900-THR4919
I	TYR4580-GLU4640
I	ASN4857-MET4879
I	GLU4900-THR4919
G	TYR4580-GLU4640
G	ASN4857-MET4879
G	GLU4900-THR4919

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175

Chain	Residue	Details
E	PRO4641-TYR4661
B	PRO4641-TYR4661
I	PRO4641-TYR4661
G	PRO4641-TYR4661

---

site_id	SWS_FT_FI4
Number of Residues	908
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175

Chain	Residue	Details
B	LYS4821-LYS4835
E	ASN4662-LYS4779
E	LYS4821-LYS4835
B	ASN4662-LYS4779
B	GLY4941-SER5037
E	GLY4941-SER5037
I	ASN4662-LYS4779
I	LYS4821-LYS4835
I	GLY4941-SER5037
G	ASN4662-LYS4779
G	LYS4821-LYS4835
G	GLY4941-SER5037

---

site_id	SWS_FT_FI5
Number of Residues	88
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175

Chain	Residue	Details
E	PHE4780-GLY4802
B	PHE4780-GLY4802
I	PHE4780-GLY4802
G	PHE4780-GLY4802

---

site_id	SWS_FT_FI6
Number of Residues	64
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175

Chain	Residue	Details
B	TYR4804-VAL4820
E	TYR4804-VAL4820
I	TYR4804-VAL4820
G	TYR4804-VAL4820

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175

Chain	Residue	Details
E	GLN4836-PHE4856
B	GLN4836-PHE4856
I	GLN4836-PHE4856
G	GLN4836-PHE4856

---

site_id	SWS_FT_FI8
Number of Residues	76
Details	INTRAMEM: Pore-forming => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175

Chain	Residue	Details
B	MET4880-ASP4899
E	MET4880-ASP4899
I	MET4880-ASP4899
G	MET4880-ASP4899

---

site_id	SWS_FT_FI9
Number of Residues	80
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175

Chain	Residue	Details
E	PHE4920-PHE4940
B	PHE4920-PHE4940
I	PHE4920-PHE4940
G	PHE4920-PHE4940

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN

Chain	Residue	Details
B	GLU3893
B	GLU3967
B	THR5001
E	GLU3893
E	GLU3967
E	THR5001
I	GLU3967
I	THR5001
G	GLU3893
G	GLU3967
G	THR5001
I	GLU3893

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5T9V, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN, ECO:0007744|PDB:5TAS, ECO:0007744|PDB:5TAT, ECO:0007744|PDB:5TAU

Chain	Residue	Details
I	THR4979
G	LYS4211
G	MET4954
G	THR4979
B	THR4979
E	LYS4211
B	LYS4211
B	MET4954
E	MET4954
E	THR4979
I	LYS4211
I	MET4954

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TAN

Chain	Residue	Details
B	TRP4716
E	TRP4716
I	TRP4716
G	TRP4716

---

site_id	SWS_FT_FI13
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:F1LMY4

Chain	Residue	Details
E	SER2345
I	UNK1470
I	SER2345
G	UNK1470
G	SER2345
B	UNK1470
B	SER2345
E	UNK1470

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA and PKG => ECO:0000269|PubMed:8380342

Chain	Residue	Details
I	SER2843
B	SER2843
E	SER2843
G	SER2843

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:10601232, ECO:0000269|PubMed:11562475, ECO:0000269|PubMed:22036948

Chain	Residue	Details
B	LEU3985
E	LEU3985
I	LEU3985
G	LEU3985

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:F1LMY4

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P21817

Chain	Residue	Details
B	TYR4863
E	TYR4863
I	TYR4863
G	TYR4863

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21817

Chain	Residue	Details
B	SER4866
E	SER4866
I	SER4866
G	SER4866

---