5T9M

Structure of rabbit RyR1 (Ca2+-only dataset, class 1)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002027	biological_process	regulation of heart rate
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005102	molecular_function	signaling receptor binding
A	0005246	molecular_function	calcium channel regulator activity
A	0005515	molecular_function	protein binding
A	0005528	molecular_function	FK506 binding
A	0005737	cellular_component	cytoplasm
A	0006458	biological_process	'de novo' protein folding
A	0006939	biological_process	smooth muscle contraction
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0009749	biological_process	response to glucose
A	0010459	biological_process	negative regulation of heart rate
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0016853	molecular_function	isomerase activity
A	0019227	biological_process	neuronal action potential propagation
A	0019722	biological_process	calcium-mediated signaling
A	0019855	molecular_function	calcium channel inhibitor activity
A	0030018	cellular_component	Z disc
A	0030073	biological_process	insulin secretion
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0034704	cellular_component	calcium channel complex
A	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
A	0042026	biological_process	protein refolding
A	0042098	biological_process	T cell proliferation
A	0044325	molecular_function	transmembrane transporter binding
A	0050849	biological_process	negative regulation of calcium-mediated signaling
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
A	0051284	biological_process	positive regulation of sequestering of calcium ion
A	0051604	biological_process	protein maturation
A	0051775	biological_process	response to redox state
A	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
B	0000166	molecular_function	nucleotide binding
B	0003151	biological_process	outflow tract morphogenesis
B	0005216	molecular_function	monoatomic ion channel activity
B	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
B	0005245	molecular_function	voltage-gated calcium channel activity
B	0005262	molecular_function	calcium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005524	molecular_function	ATP binding
B	0005790	cellular_component	smooth endoplasmic reticulum
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0006936	biological_process	muscle contraction
B	0006941	biological_process	striated muscle contraction
B	0008144	molecular_function	obsolete drug binding
B	0014802	cellular_component	terminal cisterna
B	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0015278	molecular_function	intracellularly gated calcium channel activity
B	0015643	molecular_function	toxic substance binding
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0019722	biological_process	calcium-mediated signaling
B	0030018	cellular_component	Z disc
B	0031090	cellular_component	organelle membrane
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034704	cellular_component	calcium channel complex
B	0035381	molecular_function	ATP-gated ion channel activity
B	0042383	cellular_component	sarcolemma
B	0042802	molecular_function	identical protein binding
B	0043588	biological_process	skin development
B	0043931	biological_process	ossification involved in bone maturation
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0048741	biological_process	skeletal muscle fiber development
B	0051209	biological_process	release of sequestered calcium ion into cytosol
B	0051289	biological_process	protein homotetramerization
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0071277	biological_process	cellular response to calcium ion
B	0071313	biological_process	cellular response to caffeine
B	0097718	molecular_function	disordered domain specific binding
B	1990425	cellular_component	ryanodine receptor complex
E	0000166	molecular_function	nucleotide binding
E	0003151	biological_process	outflow tract morphogenesis
E	0005216	molecular_function	monoatomic ion channel activity
E	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
E	0005245	molecular_function	voltage-gated calcium channel activity
E	0005262	molecular_function	calcium channel activity
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005516	molecular_function	calmodulin binding
E	0005524	molecular_function	ATP binding
E	0005790	cellular_component	smooth endoplasmic reticulum
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0006936	biological_process	muscle contraction
E	0006941	biological_process	striated muscle contraction
E	0008144	molecular_function	obsolete drug binding
E	0014802	cellular_component	terminal cisterna
E	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0015278	molecular_function	intracellularly gated calcium channel activity
E	0015643	molecular_function	toxic substance binding
E	0016020	cellular_component	membrane
E	0016529	cellular_component	sarcoplasmic reticulum
E	0019722	biological_process	calcium-mediated signaling
E	0030018	cellular_component	Z disc
E	0031090	cellular_component	organelle membrane
E	0033017	cellular_component	sarcoplasmic reticulum membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034704	cellular_component	calcium channel complex
E	0035381	molecular_function	ATP-gated ion channel activity
E	0042383	cellular_component	sarcolemma
E	0042802	molecular_function	identical protein binding
E	0043588	biological_process	skin development
E	0043931	biological_process	ossification involved in bone maturation
E	0044325	molecular_function	transmembrane transporter binding
E	0046872	molecular_function	metal ion binding
E	0048741	biological_process	skeletal muscle fiber development
E	0051209	biological_process	release of sequestered calcium ion into cytosol
E	0051289	biological_process	protein homotetramerization
E	0055085	biological_process	transmembrane transport
E	0070588	biological_process	calcium ion transmembrane transport
E	0071277	biological_process	cellular response to calcium ion
E	0071313	biological_process	cellular response to caffeine
E	0097718	molecular_function	disordered domain specific binding
E	1990425	cellular_component	ryanodine receptor complex
F	0002027	biological_process	regulation of heart rate
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005102	molecular_function	signaling receptor binding
F	0005246	molecular_function	calcium channel regulator activity
F	0005515	molecular_function	protein binding
F	0005528	molecular_function	FK506 binding
F	0005737	cellular_component	cytoplasm
F	0006458	biological_process	'de novo' protein folding
F	0006939	biological_process	smooth muscle contraction
F	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
F	0009749	biological_process	response to glucose
F	0010459	biological_process	negative regulation of heart rate
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016529	cellular_component	sarcoplasmic reticulum
F	0016853	molecular_function	isomerase activity
F	0019227	biological_process	neuronal action potential propagation
F	0019722	biological_process	calcium-mediated signaling
F	0019855	molecular_function	calcium channel inhibitor activity
F	0030018	cellular_component	Z disc
F	0030073	biological_process	insulin secretion
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0034704	cellular_component	calcium channel complex
F	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
F	0042026	biological_process	protein refolding
F	0042098	biological_process	T cell proliferation
F	0044325	molecular_function	transmembrane transporter binding
F	0050849	biological_process	negative regulation of calcium-mediated signaling
F	0051209	biological_process	release of sequestered calcium ion into cytosol
F	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
F	0051284	biological_process	positive regulation of sequestering of calcium ion
F	0051604	biological_process	protein maturation
F	0051775	biological_process	response to redox state
F	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
G	0000166	molecular_function	nucleotide binding
G	0003151	biological_process	outflow tract morphogenesis
G	0005216	molecular_function	monoatomic ion channel activity
G	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
G	0005245	molecular_function	voltage-gated calcium channel activity
G	0005262	molecular_function	calcium channel activity
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005790	cellular_component	smooth endoplasmic reticulum
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0006874	biological_process	intracellular calcium ion homeostasis
G	0006936	biological_process	muscle contraction
G	0006941	biological_process	striated muscle contraction
G	0008144	molecular_function	obsolete drug binding
G	0014802	cellular_component	terminal cisterna
G	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G	0015278	molecular_function	intracellularly gated calcium channel activity
G	0015643	molecular_function	toxic substance binding
G	0016020	cellular_component	membrane
G	0016529	cellular_component	sarcoplasmic reticulum
G	0019722	biological_process	calcium-mediated signaling
G	0030018	cellular_component	Z disc
G	0031090	cellular_component	organelle membrane
G	0033017	cellular_component	sarcoplasmic reticulum membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034704	cellular_component	calcium channel complex
G	0035381	molecular_function	ATP-gated ion channel activity
G	0042383	cellular_component	sarcolemma
G	0042802	molecular_function	identical protein binding
G	0043588	biological_process	skin development
G	0043931	biological_process	ossification involved in bone maturation
G	0044325	molecular_function	transmembrane transporter binding
G	0046872	molecular_function	metal ion binding
G	0048741	biological_process	skeletal muscle fiber development
G	0051209	biological_process	release of sequestered calcium ion into cytosol
G	0051289	biological_process	protein homotetramerization
G	0055085	biological_process	transmembrane transport
G	0070588	biological_process	calcium ion transmembrane transport
G	0071277	biological_process	cellular response to calcium ion
G	0071313	biological_process	cellular response to caffeine
G	0097718	molecular_function	disordered domain specific binding
G	1990425	cellular_component	ryanodine receptor complex
H	0002027	biological_process	regulation of heart rate
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005102	molecular_function	signaling receptor binding
H	0005246	molecular_function	calcium channel regulator activity
H	0005515	molecular_function	protein binding
H	0005528	molecular_function	FK506 binding
H	0005737	cellular_component	cytoplasm
H	0006458	biological_process	'de novo' protein folding
H	0006939	biological_process	smooth muscle contraction
H	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
H	0009749	biological_process	response to glucose
H	0010459	biological_process	negative regulation of heart rate
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016529	cellular_component	sarcoplasmic reticulum
H	0016853	molecular_function	isomerase activity
H	0019227	biological_process	neuronal action potential propagation
H	0019722	biological_process	calcium-mediated signaling
H	0019855	molecular_function	calcium channel inhibitor activity
H	0030018	cellular_component	Z disc
H	0030073	biological_process	insulin secretion
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0034704	cellular_component	calcium channel complex
H	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
H	0042026	biological_process	protein refolding
H	0042098	biological_process	T cell proliferation
H	0044325	molecular_function	transmembrane transporter binding
H	0050849	biological_process	negative regulation of calcium-mediated signaling
H	0051209	biological_process	release of sequestered calcium ion into cytosol
H	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
H	0051284	biological_process	positive regulation of sequestering of calcium ion
H	0051604	biological_process	protein maturation
H	0051775	biological_process	response to redox state
H	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus
I	0000166	molecular_function	nucleotide binding
I	0003151	biological_process	outflow tract morphogenesis
I	0005216	molecular_function	monoatomic ion channel activity
I	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
I	0005245	molecular_function	voltage-gated calcium channel activity
I	0005262	molecular_function	calcium channel activity
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005516	molecular_function	calmodulin binding
I	0005524	molecular_function	ATP binding
I	0005790	cellular_component	smooth endoplasmic reticulum
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006816	biological_process	calcium ion transport
I	0006874	biological_process	intracellular calcium ion homeostasis
I	0006936	biological_process	muscle contraction
I	0006941	biological_process	striated muscle contraction
I	0008144	molecular_function	obsolete drug binding
I	0014802	cellular_component	terminal cisterna
I	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I	0015278	molecular_function	intracellularly gated calcium channel activity
I	0015643	molecular_function	toxic substance binding
I	0016020	cellular_component	membrane
I	0016529	cellular_component	sarcoplasmic reticulum
I	0019722	biological_process	calcium-mediated signaling
I	0030018	cellular_component	Z disc
I	0031090	cellular_component	organelle membrane
I	0033017	cellular_component	sarcoplasmic reticulum membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0034704	cellular_component	calcium channel complex
I	0035381	molecular_function	ATP-gated ion channel activity
I	0042383	cellular_component	sarcolemma
I	0042802	molecular_function	identical protein binding
I	0043588	biological_process	skin development
I	0043931	biological_process	ossification involved in bone maturation
I	0044325	molecular_function	transmembrane transporter binding
I	0046872	molecular_function	metal ion binding
I	0048741	biological_process	skeletal muscle fiber development
I	0051209	biological_process	release of sequestered calcium ion into cytosol
I	0051289	biological_process	protein homotetramerization
I	0055085	biological_process	transmembrane transport
I	0070588	biological_process	calcium ion transmembrane transport
I	0071277	biological_process	cellular response to calcium ion
I	0071313	biological_process	cellular response to caffeine
I	0097718	molecular_function	disordered domain specific binding
I	1990425	cellular_component	ryanodine receptor complex
J	0002027	biological_process	regulation of heart rate
J	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
J	0005102	molecular_function	signaling receptor binding
J	0005246	molecular_function	calcium channel regulator activity
J	0005515	molecular_function	protein binding
J	0005528	molecular_function	FK506 binding
J	0005737	cellular_component	cytoplasm
J	0006458	biological_process	'de novo' protein folding
J	0006939	biological_process	smooth muscle contraction
J	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
J	0009749	biological_process	response to glucose
J	0010459	biological_process	negative regulation of heart rate
J	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J	0016020	cellular_component	membrane
J	0016529	cellular_component	sarcoplasmic reticulum
J	0016853	molecular_function	isomerase activity
J	0019227	biological_process	neuronal action potential propagation
J	0019722	biological_process	calcium-mediated signaling
J	0019855	molecular_function	calcium channel inhibitor activity
J	0030018	cellular_component	Z disc
J	0030073	biological_process	insulin secretion
J	0033017	cellular_component	sarcoplasmic reticulum membrane
J	0034704	cellular_component	calcium channel complex
J	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
J	0042026	biological_process	protein refolding
J	0042098	biological_process	T cell proliferation
J	0044325	molecular_function	transmembrane transporter binding
J	0050849	biological_process	negative regulation of calcium-mediated signaling
J	0051209	biological_process	release of sequestered calcium ion into cytosol
J	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
J	0051284	biological_process	positive regulation of sequestering of calcium ion
J	0051604	biological_process	protein maturation
J	0051775	biological_process	response to redox state
J	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 5101

Chain	Residue
B	CYS4958
B	CYS4961
B	HIS4978
B	HIS4983

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CA B 5102

Chain	Residue
B	GLU3893
B	GLU3967
B	THR5001

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN E 5101

Chain	Residue
E	HIS4978
E	HIS4983
E	CYS4958
E	CYS4961

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CA E 5102

Chain	Residue
E	GLU3893
E	GLU3967
E	THR5001

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN I 5101

Chain	Residue
I	CYS4958
I	CYS4961
I	HIS4978
I	HIS4983

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CA I 5102

Chain	Residue
I	GLU3893
I	GLU3967
I	THR5001

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN G 5101

Chain	Residue
G	CYS4958
G	CYS4961
G	HIS4978
G	HIS4983

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CA G 5102

Chain	Residue
G	GLU3893
G	GLU3967
G	THR5001

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	352
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	220
Details	Domain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	180
Details	Domain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	216
Details	Domain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	252
Details	Domain: {"description":"MIR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	232
Details	Domain: {"description":"MIR 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	864
Details	Domain: {"description":"B30.2/SPRY 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00548","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	44
Details	Region: {"description":"Interaction with FKBP1A","evidences":[{"source":"PubMed","id":"26245150","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	308
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	208
Details	Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"F1LMY4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---