5T8J
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue GOL A 1001 |
Chain | Residue |
A | SER696 |
A | PHE697 |
A | LYS777 |
A | ARG779 |
A | SER853 |
A | HOH1119 |
A | HOH1132 |
site_id | AC2 |
Number of Residues | 11 |
Details | binding site for residue 77T A 1002 |
Chain | Residue |
A | LEU707 |
A | GLY708 |
A | GLN711 |
A | MET742 |
A | ARG752 |
A | PHE764 |
A | MET780 |
A | LEU873 |
A | THR877 |
A | LEU704 |
A | ASN705 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 5 |
Details | MOD_RES: Phosphotyrosine; by CSK => ECO:0000269|PubMed:17045208 |
Chain | Residue | Details |
A | ASN756 | |
A | ARG840 | |
A | ASP879 | |
A | ASP890 | |
A | MET895 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | HIS789 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by CSK and TNK2 => ECO:0000269|PubMed:17045208, ECO:0000269|PubMed:17494760, ECO:0000269|PubMed:20623637 |
Chain | Residue | Details |
A | THR800 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by CSK and TNK2 => ECO:0000269|PubMed:17045208, ECO:0000269|PubMed:17494760 |
Chain | Residue | Details |
A | ALA896 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:11121022 |
Chain | Residue | Details |
A | GLN919 |