Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 701 |
| Chain | Residue |
| A | ARG476 |
| A | TYR555 |
| A | ARG600 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 702 |
| Chain | Residue |
| A | ARG476 |
| A | TYR501 |
| A | HIS592 |
| A | ARG600 |
| A | GLU603 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue TRS A 703 |
| Chain | Residue |
| A | GLN489 |
| A | LYS536 |
| A | ASN542 |
| A | HOH867 |
| A | HOH974 |
| B | LYS161 |
| B | ASN167 |
| B | LYS377 |
| B | ASP378 |
| B | GLY379 |
| B | HOH835 |
| A | THR488 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue TRS A 704 |
| Chain | Residue |
| B | TYR437 |
| B | TRP441 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue TRS A 705 |
| Chain | Residue |
| A | MET1 |
| A | LEU507 |
| A | ARG508 |
| A | LYS511 |
| A | GLU526 |
| A | HOH803 |
| A | HOH924 |
| A | HOH951 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue TRS A 706 |
| Chain | Residue |
| A | GLY99 |
| A | PHE100 |
| A | THR101 |
| A | SER112 |
| A | ILE141 |
| A | TRP142 |
| A | ASN143 |
| A | ILE144 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue TRS A 707 |
| Chain | Residue |
| A | GLY52 |
| A | SER64 |
| A | SER66 |
| A | VAL71 |
| A | LEU97 |
| A | HOH810 |
| A | HOH824 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 701 |
| Chain | Residue |
| B | ARG476 |
| B | TYR555 |
| B | ARG600 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 702 |
| Chain | Residue |
| B | ARG476 |
| B | TYR501 |
| B | ARG600 |
| B | GLU603 |
| B | HOH1068 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue TRS B 703 |
| Chain | Residue |
| A | THR380 |
| A | LYS381 |
| A | TRP441 |
| B | LYS529 |
| B | GLU532 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue TRS B 704 |
| Chain | Residue |
| B | MET1 |
| B | LEU507 |
| B | ARG508 |
| B | HIS510 |
| B | LYS511 |
| B | PRO525 |
| B | GLU526 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue TRS B 705 |
| Chain | Residue |
| B | GLY99 |
| B | ALA110 |
| B | TYR111 |
| B | SER112 |
| B | THR123 |
| B | ILE141 |
| B | TRP142 |
| B | ASN143 |
| B | ILE144 |
| B | HOH874 |
| B | HOH1016 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue TRS B 706 |
| Chain | Residue |
| B | GLY116 |
| B | GLY117 |
| B | ALA118 |
| B | ASP119 |
| B | LYS270 |
| B | LYS394 |
| B | GLU467 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue TRS B 707 |
| Chain | Residue |
| B | ASP36 |
| B | PHE39 |
| B | GLU312 |
| B | LYS313 |
| B | ARG602 |
| B | HOH1105 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue TRS B 708 |
| Chain | Residue |
| B | GLU160 |
| B | THR375 |
| B | ALA459 |
| B | LYS463 |
| B | LYS466 |
| B | HOH1022 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide PRO A 708 and PRO A 709 |
| Chain | Residue |
| A | TRP518 |
| A | ARG562 |
| A | TYR401 |
| A | ILE406 |
| A | SER477 |
| A | ASN478 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide PRO B 709 and PRO B 710 |
| Chain | Residue |
| B | TYR401 |
| B | PHE404 |
| B | SER477 |
| B | ASN478 |
| B | TRP518 |
| B | ARG562 |
| B | HOH809 |
