5T7X
Crystal structure of HHV-4 EBNA1 DNA binding domain (patient-derived, nasopharyngeal carcinoma) bound to DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006275 | biological_process | regulation of DNA replication |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0042025 | cellular_component | host cell nucleus |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006275 | biological_process | regulation of DNA replication |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0042025 | cellular_component | host cell nucleus |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: For site-specific DNA endonuclease activity => ECO:0000269|PubMed:33482082 |
| Chain | Residue | Details |
| A | TYR518 | |
| B | TYR518 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36037477 |
| Chain | Residue | Details |
| A | LYS460 | |
| A | LYS461 | |
| B | LYS460 | |
| B | LYS461 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: covalent => ECO:0000269|PubMed:33482082 |
| Chain | Residue | Details |
| A | TYR518 | |
| B | TYR518 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Interaction dimer-dimer => ECO:0000269|PubMed:31142669 |
| Chain | Residue | Details |
| A | ARG491 | |
| B | ARG491 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Interaction dimer-dimer. Required for episome maintenance and generation of immortalized B cells in the host => ECO:0000269|PubMed:31142669, ECO:0000269|PubMed:33482082 |
| Chain | Residue | Details |
| A | TYR518 | |
| B | TYR518 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Interaction dimer-dimer => ECO:0000250|UniProtKB:P03211 |
| Chain | Residue | Details |
| A | ASP581 | |
| B | ASP581 |
