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5T6E

Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a dichloro-dimethylpyridyl-methoxy-phenyl-pyridyl-piperazine ligand

Functional Information from GO Data
ChainGOidnamespacecontents
A0004379molecular_functionglycylpeptide N-tetradecanoyltransferase activity
A0006499biological_processN-terminal protein myristoylation
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue MYA A 501
ChainResidue
AHIS146
AARG225
ALEU226
ATHR227
ATHR235
ATYR244
AALA246
ATYR248
ATHR249
ALEU254
ATYR462
ATYR147
AHOH616
AHOH629
AHOH674
AHOH678
AVAL148
APHE214
ALEU215
AILE217
AARG222
ASER223
ALYS224

site_idAC2
Number of Residues15
Detailsbinding site for residue 75R A 502
ChainResidue
APHE155
APHE157
ATHR249
AGLY251
ATYR263
AHIS265
APHE278
ASER378
ATYR393
AGLY455
ALEU492
AHOH633
AHOH634
AHOH659
AHOH713

Functional Information from PROSITE/UniProt
site_idPS00975
Number of Residues9
DetailsNMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCiHK
ChainResidueDetails
AGLU211-LYS219

site_idPS00976
Number of Residues7
DetailsNMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGaGDG
ChainResidueDetails
ALYS449-GLY455

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor; via carboxylate => ECO:0000250
ChainResidueDetails
ALEU492

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P14743
ChainResidueDetails
ALEU215
ASER223

226707

PDB entries from 2024-10-30

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