5T53

MOLECULAR BASIS FOR COHESIN ACETYLATION BY ESTABLISHMENT OF SISTER CHROMATID COHESION N-ACETYLTRANSFERASE ESCO1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0006275	biological_process	regulation of DNA replication
A	0007062	biological_process	sister chromatid cohesion
A	0034421	biological_process	post-translational protein acetylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue ACO A 901

Chain	Residue
A	GLY615
A	ILE783
A	ALA784
A	SER785
A	SER809
A	PRO811
A	THR812
A	ASP814
A	LEU817
A	PHE818
A	GLN821
A	SER770
A	HOH1001
A	HOH1002
A	HOH1006
A	ARG771
A	ILE772
A	VAL774
A	ARG779
A	ARG780
A	LYS781
A	LYS782

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 902

Chain	Residue
A	CYS619
A	CYS622
A	HIS637
A	HIS641

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ZN_FING: CCHH-type => ECO:0000269|PubMed:27803161

Chain	Residue	Details
A	VAL617-HIS641

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161, ECO:0007744|PDB:4MXE, ECO:0007744|PDB:5T53

Chain	Residue	Details
A	ILE772
A	ARG780
A	THR812

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