5T4Q

Autoinhibited E. coli ATP synthase state 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006754	biological_process	ATP biosynthetic process
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006754	biological_process	ATP biosynthetic process
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006754	biological_process	ATP biosynthetic process
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0006754	biological_process	ATP biosynthetic process
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0006754	biological_process	ATP biosynthetic process
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006754	biological_process	ATP biosynthetic process
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006754	biological_process	ATP biosynthetic process
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006754	biological_process	ATP biosynthetic process
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
H	0045259	cellular_component	proton-transporting ATP synthase complex
H	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0005886	cellular_component	plasma membrane
I	0006754	biological_process	ATP biosynthetic process
I	0015078	molecular_function	proton transmembrane transporter activity
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005886	cellular_component	plasma membrane
J	0006754	biological_process	ATP biosynthetic process
J	0015078	molecular_function	proton transmembrane transporter activity
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
J	0045259	cellular_component	proton-transporting ATP synthase complex
J	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
J	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
K	0005886	cellular_component	plasma membrane
K	0006754	biological_process	ATP biosynthetic process
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
K	0045259	cellular_component	proton-transporting ATP synthase complex
K	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0005886	cellular_component	plasma membrane
L	0006754	biological_process	ATP biosynthetic process
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016020	cellular_component	membrane
L	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
L	0045259	cellular_component	proton-transporting ATP synthase complex
L	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0005886	cellular_component	plasma membrane
M	0006754	biological_process	ATP biosynthetic process
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
M	0045259	cellular_component	proton-transporting ATP synthase complex
M	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0005886	cellular_component	plasma membrane
N	0006754	biological_process	ATP biosynthetic process
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
N	0045259	cellular_component	proton-transporting ATP synthase complex
N	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0005886	cellular_component	plasma membrane
O	0006754	biological_process	ATP biosynthetic process
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
O	0045259	cellular_component	proton-transporting ATP synthase complex
O	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0005886	cellular_component	plasma membrane
P	0006754	biological_process	ATP biosynthetic process
P	0008289	molecular_function	lipid binding
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
P	0045259	cellular_component	proton-transporting ATP synthase complex
P	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
P	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0005886	cellular_component	plasma membrane
Q	0006754	biological_process	ATP biosynthetic process
Q	0008289	molecular_function	lipid binding
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
Q	0045259	cellular_component	proton-transporting ATP synthase complex
Q	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
Q	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	1902600	biological_process	proton transmembrane transport
R	0005886	cellular_component	plasma membrane
R	0006754	biological_process	ATP biosynthetic process
R	0008289	molecular_function	lipid binding
R	0015078	molecular_function	proton transmembrane transporter activity
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
R	0045259	cellular_component	proton-transporting ATP synthase complex
R	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
R	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
R	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
R	1902600	biological_process	proton transmembrane transport
S	0005886	cellular_component	plasma membrane
S	0006754	biological_process	ATP biosynthetic process
S	0008289	molecular_function	lipid binding
S	0015078	molecular_function	proton transmembrane transporter activity
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
S	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
S	0045259	cellular_component	proton-transporting ATP synthase complex
S	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
S	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
S	1902600	biological_process	proton transmembrane transport
T	0005886	cellular_component	plasma membrane
T	0006754	biological_process	ATP biosynthetic process
T	0008289	molecular_function	lipid binding
T	0015078	molecular_function	proton transmembrane transporter activity
T	0015986	biological_process	proton motive force-driven ATP synthesis
T	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
T	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
T	0045259	cellular_component	proton-transporting ATP synthase complex
T	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
T	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
T	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
T	1902600	biological_process	proton transmembrane transport
U	0005886	cellular_component	plasma membrane
U	0006754	biological_process	ATP biosynthetic process
U	0008289	molecular_function	lipid binding
U	0015078	molecular_function	proton transmembrane transporter activity
U	0015986	biological_process	proton motive force-driven ATP synthesis
U	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
U	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
U	0045259	cellular_component	proton-transporting ATP synthase complex
U	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
U	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
U	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
U	1902600	biological_process	proton transmembrane transport
V	0005886	cellular_component	plasma membrane
V	0006754	biological_process	ATP biosynthetic process
V	0008289	molecular_function	lipid binding
V	0015078	molecular_function	proton transmembrane transporter activity
V	0015986	biological_process	proton motive force-driven ATP synthesis
V	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
V	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
V	0045259	cellular_component	proton-transporting ATP synthase complex
V	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
V	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
V	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
V	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ATP A 601

Chain	Residue
A	ARG171
A	GLN172
A	LYS175
A	ALA177
A	ARG365
A	LYS434

---

site_id	AC2
Number of Residues	11
Details	binding site for residue ATP B 601

Chain	Residue
B	GLY174
B	LYS175
B	THR176
B	ALA177
B	PHE360
B	ILE364
B	ALA367
B	GLN435
B	ARG171
B	GLN172
B	THR173

---

site_id	AC3
Number of Residues	6
Details	binding site for residue ATP C 601

Chain	Residue
C	GLN172
C	THR173
C	THR176
C	ALA177
C	ILE364
C	ARG365

---

site_id	AC4
Number of Residues	11
Details	binding site for residue ADP D 601

Chain	Residue
C	ASP350
C	VAL374
D	ALA151
D	GLY152
D	VAL153
D	GLY154
D	LYS155
D	THR156
D	VAL157
D	ILE330
D	TYR331

---

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSTS

Chain	Residue	Details
D	PRO332-SER341
A	PRO366-SER375

---

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITqEltEivsGAaA

Chain	Residue	Details
G	ILE272-ALA285

---

site_id	PS00389
Number of Residues	20
Details	ATPASE_DELTA ATP synthase delta (OSCP) subunit signature. VkLnakIDkSVmAGVIIRaG

Chain	Residue	Details
L	VAL136-GLY155

---

site_id	PS00449
Number of Residues	10
Details	ATPASE_A ATP synthase a subunit signature. SLGLRLFGNM

Chain	Residue	Details
K	SER206-MET215

---

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. ARQPdliplLrTqfFIvmgLvD

Chain	Residue	Details
M	ALA40-ASP61

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	TRANSMEM: Helical

Chain	Residue	Details
M	MET11-LEU31
Q	PHE53-TYR73
R	MET11-LEU31
R	PHE53-TYR73
S	MET11-LEU31
S	PHE53-TYR73
T	MET11-LEU31
T	PHE53-TYR73
U	MET11-LEU31
U	PHE53-TYR73
V	MET11-LEU31
M	PHE53-TYR73
V	PHE53-TYR73
N	MET11-LEU31
N	PHE53-TYR73
O	MET11-LEU31
O	PHE53-TYR73
P	MET11-LEU31
P	PHE53-TYR73
Q	MET11-LEU31

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	SITE: Reversibly protonated during proton transport

Chain	Residue	Details
M	ASP61
V	ASP61
N	ASP61
O	ASP61
P	ASP61
Q	ASP61
R	ASP61
S	ASP61
T	ASP61
U	ASP61

---

site_id	SWS_FT_FI3
Number of Residues	140
Details	TOPO_DOM: Periplasmic

Chain	Residue	Details
M	MET1-TYR10
Q	VAL74-ALA79
R	MET1-TYR10
R	VAL74-ALA79
S	MET1-TYR10
S	VAL74-ALA79
T	MET1-TYR10
T	VAL74-ALA79
U	MET1-TYR10
U	VAL74-ALA79
V	MET1-TYR10
M	VAL74-ALA79
V	VAL74-ALA79
N	MET1-TYR10
N	VAL74-ALA79
O	MET1-TYR10
O	VAL74-ALA79
P	MET1-TYR10
P	VAL74-ALA79
Q	MET1-TYR10

---

site_id	SWS_FT_FI4
Number of Residues	200
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
M	GLY32-GLN52
V	GLY32-GLN52
N	GLY32-GLN52
O	GLY32-GLN52
P	GLY32-GLN52
Q	GLY32-GLN52
R	GLY32-GLN52
S	GLY32-GLN52
T	GLY32-GLN52
U	GLY32-GLN52

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	MOD_RES: N-formylmethionine => ECO:0000250

Chain	Residue	Details
M	MET1
V	MET1
N	MET1
O	MET1
P	MET1
Q	MET1
R	MET1
S	MET1
T	MET1
U	MET1

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
M	ASP61	electrostatic stabiliser, proton acceptor, proton donor
K	ARG210	electrostatic stabiliser
K	ASN214	proton acceptor

---

site_id	MCSA10
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
V	ASP61	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
N	ASP61	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
O	ASP61	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA4
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
P	ASP61	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA5
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
Q	ASP61	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA6
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
R	ASP61	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA7
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
S	ASP61	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA8
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
T	ASP61	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA9
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
U	ASP61	electrostatic stabiliser, proton acceptor, proton donor

---