5T3P

Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003723	molecular_function	RNA binding
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0009132	biological_process	nucleoside diphosphate metabolic process
A	0010945	molecular_function	coenzyme A diphosphatase activity
A	0015938	biological_process	coenzyme A catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A	0030145	molecular_function	manganese ion binding
A	0030515	molecular_function	snoRNA binding
A	0036114	biological_process	medium-chain fatty-acyl-CoA catabolic process
A	0044580	biological_process	butyryl-CoA catabolic process
A	0046356	biological_process	acetyl-CoA catabolic process
A	0046872	molecular_function	metal ion binding
A	0050873	biological_process	brown fat cell differentiation
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
A	1901289	biological_process	succinyl-CoA catabolic process
A	1902858	biological_process	propionyl-CoA metabolic process
A	1902859	biological_process	propionyl-CoA catabolic process
A	2001294	biological_process	malonyl-CoA catabolic process
B	0000287	molecular_function	magnesium ion binding
B	0003723	molecular_function	RNA binding
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0009132	biological_process	nucleoside diphosphate metabolic process
B	0010945	molecular_function	coenzyme A diphosphatase activity
B	0015938	biological_process	coenzyme A catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B	0030145	molecular_function	manganese ion binding
B	0030515	molecular_function	snoRNA binding
B	0036114	biological_process	medium-chain fatty-acyl-CoA catabolic process
B	0044580	biological_process	butyryl-CoA catabolic process
B	0046356	biological_process	acetyl-CoA catabolic process
B	0046872	molecular_function	metal ion binding
B	0050873	biological_process	brown fat cell differentiation
B	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B	1901289	biological_process	succinyl-CoA catabolic process
B	1902858	biological_process	propionyl-CoA metabolic process
B	1902859	biological_process	propionyl-CoA catabolic process
B	2001294	biological_process	malonyl-CoA catabolic process
C	0000287	molecular_function	magnesium ion binding
C	0003723	molecular_function	RNA binding
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0009132	biological_process	nucleoside diphosphate metabolic process
C	0010945	molecular_function	coenzyme A diphosphatase activity
C	0015938	biological_process	coenzyme A catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
C	0030145	molecular_function	manganese ion binding
C	0030515	molecular_function	snoRNA binding
C	0036114	biological_process	medium-chain fatty-acyl-CoA catabolic process
C	0044580	biological_process	butyryl-CoA catabolic process
C	0046356	biological_process	acetyl-CoA catabolic process
C	0046872	molecular_function	metal ion binding
C	0050873	biological_process	brown fat cell differentiation
C	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
C	1901289	biological_process	succinyl-CoA catabolic process
C	1902858	biological_process	propionyl-CoA metabolic process
C	1902859	biological_process	propionyl-CoA catabolic process
C	2001294	biological_process	malonyl-CoA catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 301

Chain	Residue
A	GLN95
A	GLU96
A	GLN136
A	ASN138

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 302

Chain	Residue
A	ASP28
A	VAL107
A	VAL108
A	CYS110

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 303

Chain	Residue
A	ARG66
A	ARG67
A	EDO304
B	LYS64
A	TYR41

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 304

Chain	Residue
A	TYR41
A	ARG66
A	LYS78
A	EDO303

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO B 301

Chain	Residue
B	ASP28
B	VAL107
B	VAL108
B	CYS109
B	CYS110
C	MET84

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO B 302

Chain	Residue
A	LYS64
B	TYR41
B	ARG66
B	ARG67
B	EDO303

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO B 303

Chain	Residue
B	TYR41
B	ARG66
B	LYS78
B	EDO302

---

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO C 301

Chain	Residue
C	TYR187
C	GLN188

---

site_id	AC9
Number of Residues	6
Details	binding site for residue EDO C 302

Chain	Residue
C	ASN39
C	TYR41
C	ARG66
C	ARG67
C	LYS78
C	EDO303

---

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO C 303

Chain	Residue
C	TYR41
C	LYS64
C	ARG66
C	ARG67
C	EDO302
C	HOH401
C	HOH430

---

Functional Information from PROSITE/UniProt

site_id	PS01293
Number of Residues	21
Details	NUDIX_COA Nudix CoA signature. LFTvRSeklRrapGevcFPGG

Chain	Residue	Details
A	LEU57-GLY77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	405
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	63
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q99P30","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"Important for coenzyme A binding","evidences":[{"source":"UniProtKB","id":"Q99P30","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99P30","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---