5T35
The PROTAC MZ1 in complex with the second bromodomain of Brd4 and pVHL:ElonginC:ElonginB
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| B | 0030891 | cellular_component | VCB complex |
| B | 0070449 | cellular_component | elongin complex |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| F | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| F | 0030891 | cellular_component | VCB complex |
| F | 0070449 | cellular_component | elongin complex |
| G | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue 759 D 301 |
| Chain | Residue |
| A | TRP374 |
| A | HOH504 |
| A | HOH507 |
| D | TRP88 |
| D | TYR98 |
| D | PRO99 |
| D | ARG107 |
| D | ILE109 |
| D | HIS110 |
| D | SER111 |
| D | TYR112 |
| A | PRO375 |
| D | HIS115 |
| D | TRP117 |
| D | HOH404 |
| D | HOH410 |
| D | HOH416 |
| A | ALA384 |
| A | LEU385 |
| A | LEU387 |
| A | ASN433 |
| A | HIS437 |
| A | GLU438 |
| A | VAL439 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue 759 H 301 |
| Chain | Residue |
| E | TRP374 |
| E | PRO375 |
| E | LEU385 |
| E | ASN433 |
| E | HIS437 |
| E | GLU438 |
| E | VAL439 |
| E | HOH507 |
| H | TRP88 |
| H | PHE91 |
| H | TYR98 |
| H | PRO99 |
| H | ARG107 |
| H | ILE109 |
| H | HIS110 |
| H | SER111 |
| H | TYR112 |
| H | HIS115 |
| H | TRP117 |
| H | HOH405 |
| H | HOH407 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 130 |
| Details | Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 110 |
| Details | Region: {"description":"Involved in binding to CCT complex"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | Region: {"description":"Interaction with Elongin BC complex"} |
| Chain | Residue | Details |
