5T18
Crystal structure of Bruton agammabulinemia tyrosine kinase complexed with BMS-986142 aka (2s)-6-fluoro-5-[3-(8-fluoro-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)-2-methylphenyl]-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004713 | molecular_function | protein tyrosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | binding site for residue 73T A 701 |
Chain | Residue |
A | THR410 |
A | TYR476 |
A | MET477 |
A | ALA478 |
A | GLY480 |
A | CYS481 |
A | ASN484 |
A | ARG525 |
A | LEU528 |
A | HOH836 |
A | HOH853 |
A | GLY411 |
A | HOH883 |
A | HOH885 |
A | HOH900 |
A | ARG422 |
A | GLY423 |
A | GLN424 |
A | ALA428 |
A | LYS430 |
A | THR474 |
A | GLU475 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 23 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK |
Chain | Residue | Details |
A | LEU408-LYS430 | |
site_id | PS00109 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV |
Chain | Residue | Details |
A | PHE517-VAL529 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ARG487 | |
Chain | Residue | Details |
A | GLU396 | |
Chain | Residue | Details |
A | ASP440 | |
Chain | Residue | Details |
A | ALA508 | |
Chain | Residue | Details |
A | PHE517 | |
Chain | Residue | Details |
A | MET570 | |
Chain | Residue | Details |
A | PHE583 | |
Chain | Residue | Details |
A | GLU589 | |
Chain | Residue | Details |
A | LYS625 | |