5T13

Structure of the Cyanuric Acid Hydrolase TrzD Reveals Product Exit Channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A	0018753	molecular_function	cyanuric acid amidohydrolase activity
A	0019381	biological_process	atrazine catabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue CO2 A 401

Chain	Residue
A	SER82
A	GLY83
A	SER233
A	ARG330
A	SER349
A	GLY350
A	HOH577
A	HOH638

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site_id	AC2
Number of Residues	5
Details	binding site for residue CO2 A 402

Chain	Residue
A	GLY235
A	ILE236
A	GLU237
A	HOH589
A	ARG51

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site_id	AC3
Number of Residues	7
Details	binding site for residue MG A 403

Chain	Residue
A	GLU303
A	SER352
A	GLN355
A	GLY356
A	PRO357
A	GLY360
A	HOH634

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01989

Chain	Residue	Details
A	LYS163

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_01989

Chain	Residue	Details
A	SER233

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site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01989

Chain	Residue	Details
A	ARG51
A	GLY356
A	PRO357
A	GLY360
A	SER82
A	ARG195
A	SER233
A	GLU303
A	ARG330
A	SER349
A	SER352
A	GLN355

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for substrate specificity => ECO:0000255|HAMAP-Rule:MF_01989

Chain	Residue	Details
A	THR326

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