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5T0N

Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0001932biological_processregulation of protein phosphorylation
A0004601molecular_functionperoxidase activity
A0005092molecular_functionGDP-dissociation inhibitor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0006111biological_processregulation of gluconeogenesis
A0006635biological_processfatty acid beta-oxidation
A0007005biological_processmitochondrion organization
A0009749biological_processresponse to glucose
A0016239biological_processpositive regulation of macroautophagy
A0016491molecular_functionoxidoreductase activity
A0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
A0030308biological_processnegative regulation of cell growth
A0030330biological_processDNA damage response, signal transduction by p53 class mediator
A0031588cellular_componentnucleotide-activated protein kinase complex
A0031932cellular_componentTORC2 complex
A0032042biological_processmitochondrial DNA metabolic process
A0032542molecular_functionsulfiredoxin activity
A0032868biological_processresponse to insulin
A0034198biological_processcellular response to amino acid starvation
A0034599biological_processcellular response to oxidative stress
A0042149biological_processcellular response to glucose starvation
A0042593biological_processglucose homeostasis
A0042731molecular_functionPH domain binding
A0044877molecular_functionprotein-containing complex binding
A0046323biological_processglucose import
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070328biological_processtriglyceride homeostasis
A0070728molecular_functionL-leucine binding
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0072593biological_processreactive oxygen species metabolic process
A0098869biological_processcellular oxidant detoxification
A0140311molecular_functionprotein sequestering activity
A1900182biological_processpositive regulation of protein localization to nucleus
A1901031biological_processregulation of response to reactive oxygen species
A1902010biological_processnegative regulation of translation in response to endoplasmic reticulum stress
A1903432biological_processregulation of TORC1 signaling
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1904504biological_processpositive regulation of lipophagy
A1990253biological_processcellular response to leucine starvation
A1990316cellular_componentAtg1/ULK1 kinase complex
B0001932biological_processregulation of protein phosphorylation
B0004601molecular_functionperoxidase activity
B0005092molecular_functionGDP-dissociation inhibitor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0006111biological_processregulation of gluconeogenesis
B0006635biological_processfatty acid beta-oxidation
B0007005biological_processmitochondrion organization
B0009749biological_processresponse to glucose
B0016239biological_processpositive regulation of macroautophagy
B0016491molecular_functionoxidoreductase activity
B0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
B0030308biological_processnegative regulation of cell growth
B0030330biological_processDNA damage response, signal transduction by p53 class mediator
B0031588cellular_componentnucleotide-activated protein kinase complex
B0031932cellular_componentTORC2 complex
B0032042biological_processmitochondrial DNA metabolic process
B0032542molecular_functionsulfiredoxin activity
B0032868biological_processresponse to insulin
B0034198biological_processcellular response to amino acid starvation
B0034599biological_processcellular response to oxidative stress
B0042149biological_processcellular response to glucose starvation
B0042593biological_processglucose homeostasis
B0042731molecular_functionPH domain binding
B0044877molecular_functionprotein-containing complex binding
B0046323biological_processglucose import
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0070328biological_processtriglyceride homeostasis
B0070728molecular_functionL-leucine binding
B0071230biological_processcellular response to amino acid stimulus
B0071233biological_processcellular response to L-leucine
B0072593biological_processreactive oxygen species metabolic process
B0098869biological_processcellular oxidant detoxification
B0140311molecular_functionprotein sequestering activity
B1900182biological_processpositive regulation of protein localization to nucleus
B1901031biological_processregulation of response to reactive oxygen species
B1902010biological_processnegative regulation of translation in response to endoplasmic reticulum stress
B1903432biological_processregulation of TORC1 signaling
B1904262biological_processnegative regulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
B1904504biological_processpositive regulation of lipophagy
B1990253biological_processcellular response to leucine starvation
B1990316cellular_componentAtg1/ULK1 kinase complex
C0001932biological_processregulation of protein phosphorylation
C0004601molecular_functionperoxidase activity
C0005092molecular_functionGDP-dissociation inhibitor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006111biological_processregulation of gluconeogenesis
C0006635biological_processfatty acid beta-oxidation
C0007005biological_processmitochondrion organization
C0009749biological_processresponse to glucose
C0016239biological_processpositive regulation of macroautophagy
C0016491molecular_functionoxidoreductase activity
C0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
C0030308biological_processnegative regulation of cell growth
C0030330biological_processDNA damage response, signal transduction by p53 class mediator
C0031588cellular_componentnucleotide-activated protein kinase complex
C0031932cellular_componentTORC2 complex
C0032042biological_processmitochondrial DNA metabolic process
C0032542molecular_functionsulfiredoxin activity
C0032868biological_processresponse to insulin
C0034198biological_processcellular response to amino acid starvation
C0034599biological_processcellular response to oxidative stress
C0042149biological_processcellular response to glucose starvation
C0042593biological_processglucose homeostasis
C0042731molecular_functionPH domain binding
C0044877molecular_functionprotein-containing complex binding
C0046323biological_processglucose import
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0070328biological_processtriglyceride homeostasis
C0070728molecular_functionL-leucine binding
C0071230biological_processcellular response to amino acid stimulus
C0071233biological_processcellular response to L-leucine
C0072593biological_processreactive oxygen species metabolic process
C0098869biological_processcellular oxidant detoxification
C0140311molecular_functionprotein sequestering activity
C1900182biological_processpositive regulation of protein localization to nucleus
C1901031biological_processregulation of response to reactive oxygen species
C1902010biological_processnegative regulation of translation in response to endoplasmic reticulum stress
C1903432biological_processregulation of TORC1 signaling
C1904262biological_processnegative regulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
C1904504biological_processpositive regulation of lipophagy
C1990253biological_processcellular response to leucine starvation
C1990316cellular_componentAtg1/ULK1 kinase complex
D0001932biological_processregulation of protein phosphorylation
D0004601molecular_functionperoxidase activity
D0005092molecular_functionGDP-dissociation inhibitor activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0006111biological_processregulation of gluconeogenesis
D0006635biological_processfatty acid beta-oxidation
D0007005biological_processmitochondrion organization
D0009749biological_processresponse to glucose
D0016239biological_processpositive regulation of macroautophagy
D0016491molecular_functionoxidoreductase activity
D0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
D0030308biological_processnegative regulation of cell growth
D0030330biological_processDNA damage response, signal transduction by p53 class mediator
D0031588cellular_componentnucleotide-activated protein kinase complex
D0031932cellular_componentTORC2 complex
D0032042biological_processmitochondrial DNA metabolic process
D0032542molecular_functionsulfiredoxin activity
D0032868biological_processresponse to insulin
D0034198biological_processcellular response to amino acid starvation
D0034599biological_processcellular response to oxidative stress
D0042149biological_processcellular response to glucose starvation
D0042593biological_processglucose homeostasis
D0042731molecular_functionPH domain binding
D0044877molecular_functionprotein-containing complex binding
D0046323biological_processglucose import
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0070328biological_processtriglyceride homeostasis
D0070728molecular_functionL-leucine binding
D0071230biological_processcellular response to amino acid stimulus
D0071233biological_processcellular response to L-leucine
D0072593biological_processreactive oxygen species metabolic process
D0098869biological_processcellular oxidant detoxification
D0140311molecular_functionprotein sequestering activity
D1900182biological_processpositive regulation of protein localization to nucleus
D1901031biological_processregulation of response to reactive oxygen species
D1902010biological_processnegative regulation of translation in response to endoplasmic reticulum stress
D1903432biological_processregulation of TORC1 signaling
D1904262biological_processnegative regulation of TORC1 signaling
D1904263biological_processpositive regulation of TORC1 signaling
D1904504biological_processpositive regulation of lipophagy
D1990253biological_processcellular response to leucine starvation
D1990316cellular_componentAtg1/ULK1 kinase complex
E0001932biological_processregulation of protein phosphorylation
E0004601molecular_functionperoxidase activity
E0005092molecular_functionGDP-dissociation inhibitor activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0006111biological_processregulation of gluconeogenesis
E0006635biological_processfatty acid beta-oxidation
E0007005biological_processmitochondrion organization
E0009749biological_processresponse to glucose
E0016239biological_processpositive regulation of macroautophagy
E0016491molecular_functionoxidoreductase activity
E0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
E0030308biological_processnegative regulation of cell growth
E0030330biological_processDNA damage response, signal transduction by p53 class mediator
E0031588cellular_componentnucleotide-activated protein kinase complex
E0031932cellular_componentTORC2 complex
E0032042biological_processmitochondrial DNA metabolic process
E0032542molecular_functionsulfiredoxin activity
E0032868biological_processresponse to insulin
E0034198biological_processcellular response to amino acid starvation
E0034599biological_processcellular response to oxidative stress
E0042149biological_processcellular response to glucose starvation
E0042593biological_processglucose homeostasis
E0042731molecular_functionPH domain binding
E0044877molecular_functionprotein-containing complex binding
E0046323biological_processglucose import
E0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E0070328biological_processtriglyceride homeostasis
E0070728molecular_functionL-leucine binding
E0071230biological_processcellular response to amino acid stimulus
E0071233biological_processcellular response to L-leucine
E0072593biological_processreactive oxygen species metabolic process
E0098869biological_processcellular oxidant detoxification
E0140311molecular_functionprotein sequestering activity
E1900182biological_processpositive regulation of protein localization to nucleus
E1901031biological_processregulation of response to reactive oxygen species
E1902010biological_processnegative regulation of translation in response to endoplasmic reticulum stress
E1903432biological_processregulation of TORC1 signaling
E1904262biological_processnegative regulation of TORC1 signaling
E1904263biological_processpositive regulation of TORC1 signaling
E1904504biological_processpositive regulation of lipophagy
E1990253biological_processcellular response to leucine starvation
E1990316cellular_componentAtg1/ULK1 kinase complex
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue LEU A 501
ChainResidue
ATHR374
ATYR375
AASN376
ATHR377
ATHR386
AARG390
AGLU451
AHIS454

site_idAC2
Number of Residues8
Detailsbinding site for residue LEU B 501
ChainResidue
BTYR375
BASN376
BTHR377
BTHR386
BARG390
BGLU451
BHIS454
BTHR374

site_idAC3
Number of Residues8
Detailsbinding site for residue LEU C 501
ChainResidue
CTHR374
CTYR375
CASN376
CTHR377
CTHR386
CARG390
CGLU451
CHIS454

site_idAC4
Number of Residues8
Detailsbinding site for residue LEU D 501
ChainResidue
DTHR374
DTYR375
DASN376
DTHR377
DTHR386
DARG390
DGLU451
DHIS454

site_idAC5
Number of Residues8
Detailsbinding site for residue LEU E 501
ChainResidue
ETHR374
ETYR375
EASN376
ETHR377
ETHR386
EARG390
EGLU451
EHIS454

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:26612684
ChainResidueDetails
ACYS125
BCYS125
CCYS125
DCYS125
ECYS125

site_idSWS_FT_FI2
Number of Residues15
DetailsBINDING: BINDING => ECO:0000269|PubMed:26586190, ECO:0007744|PDB:5DJ4
ChainResidueDetails
ATHR374
DTHR374
DTHR386
DGLU451
ETHR374
ETHR386
EGLU451
ATHR386
AGLU451
BTHR374
BTHR386
BGLU451
CTHR374
CTHR386
CGLU451

site_idSWS_FT_FI3
Number of Residues5
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AMET1
BMET1
CMET1
DMET1
EMET1

site_idSWS_FT_FI4
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER249
BSER249
CSER249
DSER249
ESER249

site_idSWS_FT_FI5
Number of Residues10
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:35114100
ChainResidueDetails
ALYS175
BLYS175
CLYS175
DLYS175
ELYS175

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PDB entries from 2024-07-24

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