5T0M
A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002039 | molecular_function | p53 binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| B | 0002039 | molecular_function | p53 binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0042054 | molecular_function | histone methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1201 |
| Chain | Residue |
| A | CYS974 |
| A | CYS987 |
| A | CYS1017 |
| A | CYS1021 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1202 |
| Chain | Residue |
| A | CYS980 |
| A | CYS1017 |
| A | CYS1023 |
| A | CYS1027 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1203 |
| Chain | Residue |
| A | CYS976 |
| A | CYS980 |
| A | CYS985 |
| A | CYS974 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1204 |
| Chain | Residue |
| A | CYS1115 |
| A | CYS1168 |
| A | CYS1170 |
| A | CYS1175 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue SAM A 1205 |
| Chain | Residue |
| A | MET1048 |
| A | TRP1050 |
| A | SER1084 |
| A | TYR1085 |
| A | ARG1109 |
| A | PHE1110 |
| A | ILE1111 |
| A | ASN1112 |
| A | HIS1113 |
| A | TYR1154 |
| A | PHE1166 |
| A | THR1167 |
| A | CYS1168 |
| A | GLN1169 |
| A | SAH1206 |
| A | HOH1404 |
| A | HOH1422 |
| A | HOH1423 |
| A | HOH1425 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | binding site for residue SAH A 1206 |
| Chain | Residue |
| A | MET1048 |
| A | TRP1050 |
| A | SER1084 |
| A | TYR1085 |
| A | ARG1109 |
| A | PHE1110 |
| A | ILE1111 |
| A | ASN1112 |
| A | HIS1113 |
| A | TYR1154 |
| A | PHE1166 |
| A | THR1167 |
| A | CYS1168 |
| A | GLN1169 |
| A | SAM1205 |
| A | HOH1404 |
| A | HOH1422 |
| A | HOH1423 |
| A | HOH1425 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1201 |
| Chain | Residue |
| B | CYS974 |
| B | CYS987 |
| B | CYS1017 |
| B | CYS1021 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1202 |
| Chain | Residue |
| B | CYS980 |
| B | CYS1017 |
| B | CYS1023 |
| B | CYS1027 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1203 |
| Chain | Residue |
| B | CYS974 |
| B | CYS976 |
| B | CYS980 |
| B | CYS985 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1204 |
| Chain | Residue |
| B | CYS1115 |
| B | CYS1168 |
| B | CYS1170 |
| B | CYS1175 |
| site_id | AD2 |
| Number of Residues | 18 |
| Details | binding site for residue SAM B 1205 |
| Chain | Residue |
| B | MET1048 |
| B | TRP1050 |
| B | SER1084 |
| B | TYR1085 |
| B | ARG1109 |
| B | PHE1110 |
| B | ILE1111 |
| B | ASN1112 |
| B | HIS1113 |
| B | TYR1154 |
| B | PHE1158 |
| B | PHE1166 |
| B | THR1167 |
| B | CYS1168 |
| B | GLN1169 |
| B | HOH1354 |
| B | HOH1402 |
| B | HOH1413 |
| site_id | AD3 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide ARG C 8 and NLE C 9 |
| Chain | Residue |
| C | LYS4 |
| C | THR6 |
| C | ALA7 |
| C | SER10 |
| C | HOH105 |
| B | TYR1067 |
| B | ASP1074 |
| B | ALA1077 |
| B | ASP1078 |
| B | LEU1086 |
| B | PHE1087 |
| B | ASP1088 |
| B | PHE1152 |
| B | TYR1154 |
| B | ARG1157 |
| B | PHE1158 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide NLE C 9 and SER C 10 |
| Chain | Residue |
| B | TYR1067 |
| B | LEU1086 |
| B | PHE1087 |
| B | ASP1088 |
| B | ASN1091 |
| B | PHE1152 |
| B | TYR1154 |
| C | ARG8 |
| C | THR11 |
| C | GLY12 |
| C | HOH105 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| P | ARG2 | |
| A | ASP1082 | |
| A | ILE1119 | |
| A | THR1146 | |
| A | GLU1149 | |
| B | LYS1008 | |
| B | GLU1010 | |
| B | ILE1014 | |
| B | GLN1019 | |
| B | CYS1021 | |
| B | GLY1051 | |
| C | ARG2 | |
| B | LEU1055 | |
| B | THR1057 | |
| B | GLY1061 | |
| B | ASP1082 | |
| B | ILE1119 | |
| B | THR1146 | |
| B | GLU1149 | |
| A | ILE1014 | |
| A | GLN1019 | |
| A | CYS1021 | |
| A | GLY1051 | |
| A | LEU1055 | |
| A | THR1057 | |
| A | GLY1061 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692 |
| Chain | Residue | Details |
| P | THR3 | |
| C | THR3 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| P | LYS4 | |
| C | LYS4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| P | GLN5 | |
| C | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| P | THR6 | |
| C | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| P | ARG8 | |
| C | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| P | NLE9 | |
| C | NLE9 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| P | SER10 | |
| C | SER10 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| P | THR11 | |
| C | THR11 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| P | LYS14 | |
| C | LYS14 |
